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The Association Stu...
The Association Study of IL-23R Polymorphisms With Cerebral Palsy in Chinese Population
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Wang, Y. G. (author)
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Xu, Y. R. (author)
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Fan, Y. Y. (author)
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Bi, D. (author)
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Song, J. (author)
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Xia, L. (author)
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Shang, Q. (author)
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Gao, C. (author)
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Zhang, X. L. (author)
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Zhu, D. N. (author)
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Qiao, Y. M. (author)
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Su, Y. (author)
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Wang, X. Y. (author)
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- Zhu, Changlian, 1964 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Xing, Q. H. (author)
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(creator_code:org_t)
- 2020-11-25
- 2020
- English.
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In: Frontiers in Neuroscience. - : Frontiers Media SA. - 1662-4548 .- 1662-453X. ; 14
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Abstract
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- Background: Cerebral palsy (CP) is a syndrome of non-progressive motor dysfunction caused by early brain development injury. Recent evidence has shown that immunological abnormalities are associated with an increased risk of CP. Methods: We recruited 782 children with CP as the case group and 770 healthy children as the control group. The association between IL-23R single nucleotide polymorphisms (SNPs; namely, rs10889657, rs6682925, rs1884444, rs17375018, rs1004819, rs11805303, and rs10889677) and CP was studied by using a case-control method and SHEsis online software. Subgroup analysis based on complications and clinical subtypes was also carried out. Results: There were differences in the allele and genotype frequencies between CP cases and controls at the rs11805303 and rs10889677 SNPs (Pallele = 0.014 and 0.048, respectively; Pgenotype = 0.023 and 0.008, respectively), and the difference in genotype frequency of rs10889677 remained significant after Bonferroni correction (Pgenotype = 0.048). Subgroup analysis revealed a more significant association of rs10889677 with CP accompanied by global developmental delay (Pgenotype = 0.024 after correction) and neonatal encephalopathy (Pgenotype = 0.024 after correction). Conclusion: The present results showed a significant association between IL-23R and CP, suggesting that IL-23R may play a potential role in CP pathogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- cerebral palsy
- inflammatory cytokines
- interleukin
- gene polymorphism
- IL23R
- sumo e3 ligase
- gene polymorphisms
- risk
- inflammation
- children
- interleukin-10
- susceptibility
- activation
- expression
- cytokine
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Wang, Y. G.
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Xu, Y. R.
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Fan, Y. Y.
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Bi, D.
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Song, J.
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Xia, L.
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show more...
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Shang, Q.
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Gao, C.
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Zhang, X. L.
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Zhu, D. N.
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Qiao, Y. M.
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Su, Y.
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Wang, X. Y.
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Zhu, Changlian, ...
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Xing, Q. H.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Frontiers in Neu ...
- By the university
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University of Gothenburg
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Karolinska Institutet