Serum neurofilament light concentration does not increase following exposure to low velocity football heading

Objectives: To investigate if heading frequency and impact biomechanics in a single session influence the concentration of serum neurofilament light (NF-L), a sensitive biomarker for axonal damage, up to 7 days after heading incident at ball velocities reflecting basic training drills. Methods: Forty-four males were randomized into either control (n = 8), 10 header (n = 12), 20 header (n = 12) or 40 header (n = 12) groups. Linear and angular head accelerations were quantified during heading. Venous blood samples were taken at baseline, 6 h, 24 h and 7 days after heading. Serum NF-L was quantified using Quanterix NF-L assay kit on the Simoa HD-1 Platform. Results: Serum NF-L did not alter over time (p = 0.44) and was not influenced by number of headers [p = 0.47; mean (95% CI) concentrations at baseline 6.00 pg center dot ml(-) (1) (5.00-7.00 pg center dot ml(-) (1)); 6 h post 6.50 pg center dot ml(-1) (5.70-7.29 pg center dot ml(-1)); 24 h post 6.07 pg center dot ml(-1) (5.14-7.01 pg center dot ml(-) (1)); and 7 days post 6.46 pg center dot ml(-1) (5.45-7.46 pg center dot ml(-1))]. There was no relationship between percentage change in NF-L and summed session linear and angular head accelerations. Conclusion: In adult men, heading frequency or impact biomechanics did not affect NF-L response during a single session of headers at ball velocities reflective of basic training tasks.

Lee, B. (author)
Flood, T. R. (author)
Toombs, J. (author)
Borisova, M. (author)
Lauder, M. (author)
Heslegrave, A. (author)
Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
Smith, N. A. (author)
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

In:Science and Medicine in Football: Informa UK Limited5:3, s. 188-1942473-39382473-4446

By the author/editor: Austin, K.; Lee, B.; Flood, T. R.; Toombs, J.; Borisova, M.; Lauder, M.; show more...; Heslegrave, A.; Zetterberg, Henr ...; Smith, N. A.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Sport and Fitnes ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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