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  • Olafsdottir, Arndis,1978University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,NU Hospital Group,NU Hosp Grp, Dept Med, Uddevalla, Sweden.;Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden. (author)

The majority of people with type 1 diabetes and multiple daily insulin injections benefit from using continuous glucose monitoring: An analysis based on the GOLD randomized trial (GOLD-5)

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2020-12-10
  • Wiley,2021

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/300917
  • https://gup.ub.gu.se/publication/300917URI
  • https://doi.org/10.1111/dom.14257DOI
  • https://lup.lub.lu.se/record/7416a7c4-49a2-453b-b643-19e81abc2950URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-172239URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145303982URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-438825URI

Supplementary language notes

  • Language:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|NU Hospital Group, Trollhattan, Sweden; Dexcom, Inc.; Swedish government (Avtalet om Lakareutbildning och Medicinsk Forskning [Agreement for Medical Education and Research]); NU Hospital Group, Uddevalla, Sweden
  • Aim To identify responders to continuous glucose monitoring (CGM) in relation to reductions in HbA1c and percentage of time spent in hypoglycaemia after initiation of CGM for individuals with type 1 diabetes treated with multiple daily insulin injections. Materials and Methods We analysed data from 142 participants in the GOLD randomized clinical trial. We evaluated how many lowered their HbA1c by more than 0.4% (>4.7 mmol/mol) or decreased the time spent in hypoglycaemia over 24 hours by more than 20 or 30 minutes, and which baseline variables were associated with those improvements. Results Lower reduction of HbA1c was associated with greater reduction of hypoglycaemia (r = -0.52; P < .0001). During CGM, 47% of participants lowered their HbA1c values by more than 0.4% (>4.7 mmol/mol) than with self-measurement of blood glucose, and 47% decreased the time spent in hypoglycaemia by more than 20 minutes over 24 hours. Overall, 78% either reduced their HbA1c by more than 0.4% (>4.7 mmol/mol) or the time spent in hypoglycaemia by more than 20 minutes over 24 hours, but only 14% improved both. Higher HbA1c, a lower percentage of time at less than 3.0 or 3.9 mmol/L, a lower coefficient of variation (CV) and a higher percentage of time above 13.9 mmol/L (P = .016) were associated with greater HbA1c reduction during CGM. The variables associated with a greater reduction of time in hypoglycaemia were female sex, greater time with glucose levels at less than 3.0 mmol/L, higher CV, and higher hypoglycaemia confidence as evaluated by a hypoglycaemic confidence questionnaire. Conclusion The majority of people with type 1 diabetes managed by multiple daily insulin injections benefit from CGM; some experienced reduced HbA1c while others reduced the time spent in hypoglycaemia. These factors need to be considered by healthcare professionals and decision-makers for reimbursement and diabetes guidelines.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Bolinder, J.Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Karolinska Univ Hosp Huddinge, Dept Med, Stockholm, Sweden. (author)
  • Heise, T.PROFIL Institut für Stoffwechselforschung GmbH,Profil, Neuss, Germany. (author)
  • Polonsky, W.University of California, San Diego,Behav Diabet Inst, San Diego, CA USA.;Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA. (author)
  • Ekelund, MagnusLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Lund Univ, Dept Clin Sci, Lund, Sweden.(Swepub:lu)ma2086ek (author)
  • Wijkman, MagnusLinköpings universitet,Linköping University,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Medicinkliniken ViN,Linköping Univ, Dept Internal Med, Norrköping, Sweden.;Linköping Univ, Dept Hlth Med & Caring Sci, Norrköping, Sweden.(Swepub:liu)magwi58 (author)
  • Pivodic, Aldina,1978University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Statistiska Konsultgruppen, Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Clin Neurosci, Gothenburg, Sweden.(Swepub:gu)xpival (author)
  • Ahlén, Elsa,1990University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,NU Hospital Group,NU Hosp Grp, Dept Med, Uddevalla, Sweden.;Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden.(Swepub:gu)xahlee (author)
  • Schwarcz, E.Örebro University,Örebro Univ, Fac Med & Hlth, Dept Internal Med, Örebro, Sweden. (author)
  • Nystrom, T.Karolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, Stockholm, Sweden. (author)
  • Hellman, JarlUppsala universitet,Uppsala University,Uppsala Univ, Sweden,Klinisk diabetologi och metabolism(Swepub:uu)jarlhell (author)
  • Hirsch, I. B.University of Washington,Univ Washington, Sch Med, Seattle, WA USA. (author)
  • Lind, Marcus,1976University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,NU Hospital Group,NU Hosp Grp, Dept Med, Uddevalla, Sweden.;Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden.(Swepub:gu)xostem (author)
  • Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin (creator_code:org_t)

Related titles

  • In:Diabetes Obesity & Metabolism: Wiley23:2, s. 619-6301462-89021463-1326

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