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Primary treatment a...
Primary treatment and relative survival by stage and age in vulvar squamous cell carcinoma: A population-based SweGCG study
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- Hellman, K. (author)
- Karolinska Univ Hosp, Dept Gynecol Canc, Theme Canc, SE-17176 Stockholm, Sweden.,Karolinska University Hospital
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- Holmberg, Erik, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Reg Canc Ctr West, Reg Vastra Gotaland, SE-41345 Gothenburg, Sweden.;Sahlgrens Acad, Inst Clin Sci, Dept Oncol, SE-41345 Gothenburg, Sweden.,Sahlgrenska Academy,Regional Cancer Center Western Sweden
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- Bjurberg, Maria (author)
- Lund Univ, Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Dept Clin Sci, SE-22185 Lund, Sweden.,Skåne University Hospital
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- Borgfeldt, Christer (author)
- Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skane Univ Hosp, Sweden; Lund Univ, Sweden
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- Dahm-Kähler, Pernilla, 1964 (author)
- Sahlgrens Univ Hosp, Dept Obstet & Gynecol, SE-41345 Gothenburg, Sweden.,Sahlgrenska University Hospital
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- Flöter Rådestad, A. (author)
- Karolinska Institutet
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- Hjerpe, E. (author)
- Visby Hosp, Dept Obstet & Gynecol, SE-62155 Visby, Sweden.,Visby hospital
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- Högberg, Thomas (author)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Sweden
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- Marcickiewicz, J. (author)
- Halland Hosp, Dept Obstet & Gynecol, SE-43281 Varberg, Sweden.,Hallands sjukhus, Varberg
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- Rosenberg, Per (author)
- Linköpings universitet,Linköping University,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
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- Stålberg, Karin (author)
- Uppsala University,Uppsala universitet,Reproduktiv hälsa,Uppsala Univ, Sweden
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- Tholander, Bengt (author)
- Uppsala universitet,Experimentell och klinisk onkologi,Uppsala University Hospital,Uppsala Univ Hosp, Sweden
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- Kjölhede, Preben (author)
- Linköpings universitet,Linköping University,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Kvinnokliniken US
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- Åvall Lundqvist, Elisabeth (author)
- Linköpings universitet,Linköping University,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
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Karolinska Univ Hosp, Dept Gynecol Canc, Theme Canc, SE-17176 Stockholm, Sweden Karolinska University Hospital (creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: Gynecologic Oncology. - : Elsevier BV. - 0090-8258 .- 1095-6859. ; 159:3, s. 663-671
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Abstract
Subject headings
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- Objective: Vulvar cancer affects mainly elderly women and with an ageing population the incidence has increased. We explored the primary treatment patterns and relative survival of patients with vulvar squamous cell carcinoma (VSCC) by stage and age-group. Methods: A population-based nationwide study on women diagnosed with VSCC between 2012 and 2016 and registered in the Swedish Quality Registry for Gynecologic Cancer (SQRGC). Main outcome was 5-year relative survival (RS) estimated by the Pohar Perme method. The relative risk of excess mortality (EMRR) between different groups was analyzed by Poisson regression. The age-standardized relative survival (AS-RS) was estimated for the total cohort. Results: Median follow-up time was 41 months. The study population included 657 women; 33% were ≥ 80 years old. FIGO stage I was most common (55%). Primary surgery was performed in 96% stage I, 65% stage II, 80% stage III and 28% stage IV. In women ≥80 years, exploration of the groins and chemoradiotherapy was less often performed. They also received lower mean doses of radiation than younger women. The 5-year AS-RS was 74%. 5-year RS was 84% for stage I, 60% for stage II, 54% for stage III and 35% for stage IV. The EMRR for women ≥80 years compared with women <60 years was 4.3 (p < 0.001); 4.9 (p < 0.001) for stages I-II and 3.5(p = 0.007) for stage III. Conclusions: In general, primary treatment of patients with vulvar squamous cell carcinoma in Sweden adhered to guidelines. Areas of improvement include treatment for stage II and for the very old. © 2020 Elsevier Inc.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Age
- Stage
- Survival
- Treatment
- Vulvar cancer
- Vulvar cancer
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hellman, K.
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Holmberg, Erik, ...
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Bjurberg, Maria
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Borgfeldt, Chris ...
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Dahm-Kähler, Per ...
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Flöter Rådestad, ...
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show more...
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Hjerpe, E.
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Högberg, Thomas
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Marcickiewicz, J ...
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Rosenberg, Per
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Stålberg, Karin
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Tholander, Bengt
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Kjölhede, Preben
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Åvall Lundqvist, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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Gynecologic Onco ...
- By the university
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University of Gothenburg
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Uppsala University
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Lund University
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Linköping University
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Karolinska Institutet