Search: onr:"swepub:oai:gup.ub.gu.se/301408" > Nerve growth factor...
Fältnamn | Indikatorer | Metadata |
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000 | 05018naa a2200613 4500 | |
001 | oai:gup.ub.gu.se/301408 | |
003 | SwePub | |
008 | 240910s2021 | |||||||||||000 ||eng| | |
009 | oai:slubar.slu.se:110279 | |
024 | 7 | a https://gup.ub.gu.se/publication/3014082 URI |
024 | 7 | a https://doi.org/10.1016/j.tvjl.2020.1055792 DOI |
024 | 7 | a https://res.slu.se/id/publ/1102792 URI |
040 | a (SwePub)gud (SwePub)slu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Kendall, Annau Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health4 aut0 (Swepub:slu)51201 |
245 | 1 0 | a Nerve growth factor in the equine joint |
264 | 1 | b Elsevier BV,c 2021 |
520 | a Nerve growth factor (NGF) is a neurotrophin with many functions. In humans, it is involved in inflammation, nerve growth, apoptosis and pain signalling. Increased concentrations of NGF in synovial fluid has been shown in humans and dogs with osteoarthritis. Despite osteoarthritis being a common problem in horses, no studies have previously been published on NGF in the equine joint. The aim of this study was to quantify NGF in equine synovial fluid from healthy joints, acutely inflamed septic joints and joints with structural changes associated with osteoarthritis. A secondary aim was to identify the localisation of NGF and its two receptors, TrkA and p75(NTR) in healthy and osteoarthritic articular cartilage. NGF concentrations in synovial fluid from osteoarthritic joints (n = 27), septic joints (n = 9) and healthy joints (n = 16) were determined by ELISA. In addition, articular cartilage from osteoarthritic and healthy joints was examined for NGF, TrkA and P75(NTR) using immunohistochemistry staining. NGF was present in equine synovial fluid and articular cartilage. Compared to synovial fluid from healthy joints, NGF concentration was higher in synovial fluid from joints with structural osteoarthritic changes (P = 0.032) or acute septic inflammation (P = 0.006). In articular cartilage with severe osteoarthritic changes, there was more abundant positive immunohistochemistry staining for NGF and its receptors than in normal articular cartilage. Further studies should focus on identifying precursor forms of NGF, and on receptor expression and downstream signalling of TrkA and P75(NTR) in health and disease. (C) 2020 The Author(s). Published by Elsevier Ltd. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a LANTBRUKSVETENSKAPERx Veterinärmedicinx Patobiologi0 (SwePub)403022 hsv//swe |
650 | 7 | a AGRICULTURAL SCIENCESx Veterinary Sciencex Pathobiology0 (SwePub)403022 hsv//eng |
653 | a Horse | |
653 | a Joint | |
653 | a Nerve | |
653 | a Growth factor | |
653 | a Osteoarthritis | |
653 | a swedish horses | |
653 | a pain | |
653 | a osteoarthritis | |
653 | a survival | |
653 | a prongf | |
653 | a breed | |
653 | a knee | |
653 | a dogs | |
653 | a sex | |
653 | a age | |
653 | a Veterinary Sciences | |
700 | 1 | a Ekman, Stinau Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health4 aut0 (Swepub:slu)47073 |
700 | 1 | a Mattsson Hultén, Lillemor,d 1951u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xmatli |
700 | 1 | a Lindahl, A.4 aut |
700 | 1 | a Hansson, Elisabeth,d 1955u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xhanse |
700 | 1 | a Skiöldebrand, Evau Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health4 aut0 (Swepub:slu)50022 |
710 | 2 | a Sveriges lantbruksuniversitetb Inst för biomedicin och veterinär folkhälsovetenskap4 org |
710 | 2 | a Sveriges lantbruksuniversitet |
773 | 0 | t Veterinary Journald : Elsevier BVg 267q 267x 1090-0233x 1532-2971 |
856 | 4 | u https://doi.org/10.1016/j.tvjl.2020.105579 |
856 | 4 | u https://pub.epsilon.slu.se/id/eprint/22797/contentsx primaryx Raw objectx freey FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/301408 |
856 | 4 8 | u https://doi.org/10.1016/j.tvjl.2020.105579 |
856 | 4 8 | u https://res.slu.se/id/publ/110279 |
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