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Early Metabolic and...
Early Metabolic and Inflammatory Intraperitoneal Changes After Rectum Perforation
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- Oikonomakis, Ioannis, 1977- (author)
- Department of Surgery, Örebro University Hospital, Örebro, Sweden
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- Hörer, Tal M., 1971- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Cardiothoracic and Vascular
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- Skoog, Per (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Vascular Surgery and Institute of Medicine, Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital and Academy, Gothenburg, Sweden, Gothenburg, Sweden
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- Nilsson, Kristofer F., 1981- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiothoracic and Vascular
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- Jansson, K. (author)
- Department of Surgery, Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- Korean Society of Coloproctology, 2020
- 2020
- English.
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In: Annals of Coloproctology. - : Korean Society of Coloproctology. - 2287-9714 .- 2287-9722. ; 36:6, s. 374-381
- Related links:
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https://coloproctol....
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https://doi.org/10.3...
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Purpose: Anastomotic leakage (AL) is the most dreaded complication in rectal surgery. It has a great impact on postoperative morbidity and mortality. This animal model, in which we have studied postoperative metabolic and inflammatory changes, is designed to imitate an AL. Methods: Twelve pigs were randomized into 2 groups. In the experimental group, an iatrogenic rectal perforation was performed, with the control group having a sham operation. The 2 groups were followed for 10 hours after operation with regard to vital parameters, arterial lactate, and cytokines interleukin (IL) 1, IL6, and IL10 in the blood and intraperitoneally. Intraperitoneal microdialysis analyses of glucose, lactate, glycerol, and pyruvate were performed and the lactate/pyruvate ratio was calculated. Results: Glucose levels were lower in the experimental group after 4 hours. After 7 hours, lactate and lactate/pyruvate ratio was higher in the experimental group. At the same time intraperitoneal cytokines IL6 and IL10 were higher in the experimental group. Blood samples showed higher IL6 after 7 hours in the experimental group. Conclusion: In this study, several significant differences between the groups in metabolic and inflammatory values were detected. Further clinical studies are recommended to evaluate the importance of intraperitoneal metabolic and inflammatory analyses as a diagnostic tool for early identification of an AL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Colorectal surgery
- Anastomotic leak
- Intraperitoneal metabolism
- Intraperitoneal microdialysis
- Intraperitoneal cytokines
- low anterior resection
- anastomotic leakage
- microdialysis
- complications
- diagnosis
- surgery
- cancer
- hypertension
- Gastroenterology & Hepatology
- Surgery
- Rectal surgery
Publication and Content Type
- ref (subject category)
- art (subject category)
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