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DrugCentral 2021 su...
DrugCentral 2021 supports drug discovery and repositioning
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Avram, S. (author)
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Bologa, C. G. (author)
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Holmes, J. (author)
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Bocci, G. (author)
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Wilson, T. B. (author)
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Nguyen, D. T. (author)
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Curpan, R. (author)
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Halip, L. (author)
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Bora, A. (author)
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Yang, J. J. (author)
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Knockel, J. (author)
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Sirimulla, S. (author)
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Ursu, O. (author)
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- Oprea, Tudor I (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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(creator_code:org_t)
- 2020-11-05
- 2021
- English.
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In: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 49:D1
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https://doi.org/10.1...
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Abstract
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- DrugCentral is a public resource (http://drugcentral.org) that serves the scientific community by providing up-to-date drug information, as described in previous papers. The current release includes 109 newly approved (October 2018 through March 2020) active pharmaceutical ingredients in the US, Europe, Japan and other countries; and two molecular entities (e.g. mefuparib) of interest for COVID19. New additions include a set of pharmacokinetic properties for similar to 1000 drugs, and a sex-based separation of side effects, processed from FAERS (FDA Adverse Event Reporting System); as well as a drug repositioning prioritization scheme based on the market availability and intellectual property rights forFDA approved drugs. In the context of the COVID19 pandemic, we also incorporated REDIAL-2020, a machine learning platform that estimates anti-SARS-CoV-2 activities, as well as the `drugs in news' feature offers a brief enumeration of the most interesting drugs at the present moment. The full database dump and data files are available for download fromthe DrugCentral web portal.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- trials
- Biochemistry & Molecular Biology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Avram, S.
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Bologa, C. G.
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Holmes, J.
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Bocci, G.
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Wilson, T. B.
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Nguyen, D. T.
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show more...
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Curpan, R.
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Halip, L.
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Bora, A.
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Yang, J. J.
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Knockel, J.
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Sirimulla, S.
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Ursu, O.
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Oprea, Tudor I
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Nucleic Acids Re ...
- By the university
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University of Gothenburg