Significant salivary changes in relation to oral mucositis following autologous hematopoietic stem cell transplantation

The aim of this multicentre, longitudinal study was to determine salivary changes in relation to oral mucositis (OM) in multiple myeloma patients following high-dose melphalan and autologous hematopoietic stem cell transplantation (ASCT). Unstimulated and stimulated whole-mouth saliva samples (UWS and SWS) were collected before ASCT, 1x/wk during the hospitalisation phase, and 3 and 12 months post-ASCT. During the hospitalisation period OM was scored 3x/wk (WHO system). Flow rate, pH, total protein concentration (Nanodrop), albumin, lactoferrin, neutrophil defensin-1 (HNP1), total IgA and S100A8/A9 (ELISA) were determined. Mixed models were used to evaluate differences between ulcerative (u)OM (>= 2 WHO, n = 20) and non-uOM (n = 31) groups. Until 18 days after ASCT, flow rate, pH, total IgA and HNP1 levels decreased in UWS and/or SWS, while log lactoferrin levels were significantly increased (UWS: p = 0.016 95% CI [0.36, 3.58], SWS: p < 0.001 95% CI [1.14, 3.29]). Twelve months post-ASCT, salivary protein levels were similar to baseline except for log total IgA, which was higher (UWS: p < 0.001 95% CI [0.49, 1.29], SWS: p < 0.001 95% CI [0.72, 1.45]). No differences between uOM and non-uOM groups were observed. Changes in salivary proteins indicated an inflammatory reaction in salivary glands coinciding with mucosal and systemic reactions in response to high-dose melphalan.

Proctor, G. B. (author)
Laheij, Amga (author)
Potting, C. M. J. (author)
Smits, O. (author)
Bronkhorst, E. M. (author)
Hazenberg, M. D. (author)
Haverman, T. M. (author)
Brennan, M. T. (author)
von Bültzingslöwen, Inger,1947Gothenburg University,Göteborgs universitet,Institutionen för odontologi, sektion 3,Institute of Odontology, Section 3(Swepub:gu)xvonin (author)
Raber-Durlacher, J. E. (author)
Huysmans, Mcdnjm (author)
Rozema, F. R. (author)
Blijlevens, N. M. A. (author)
Göteborgs universitetInstitutionen för odontologi, sektion 3 (creator_code:org_t)

In:Bone Marrow Transplantation: Springer Science and Business Media LLC0268-33691476-5365

By the author/editor: van Leeuwen, S. ...; Proctor, G. B.; Laheij, Amga; Potting, C. M. J ...; Smits, O.; Bronkhorst, E. M ...; show more...; Hazenberg, M. D.; Haverman, T. M.; Brennan, M. T.; von Bültzingslöw ...; Raber-Durlacher, ...; Huysmans, Mcdnjm; Rozema, F. R.; Blijlevens, N. M ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dentistry

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