Search: onr:"swepub:oai:gup.ub.gu.se/302280" >
Violacein-Induced C...
Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity.
-
Tavella, Tatyana Almeida (author)
-
da Silva, Noeli Soares Melo (author)
-
Spillman, Natalie (author)
-
show more...
-
Kayano, Ana Carolina Andrade Vitor (author)
-
Cassiano, Gustavo Capatti (author)
-
Vasconcelos, Adrielle Ayumi (author)
-
Camargo, Antônio Pedro (author)
-
da Silva, Djane Clarys Baia (author)
-
Fontinha, Diana (author)
-
Salazar Alvarez, Luis Carlos (author)
-
Ferreira, Letícia Tiburcio (author)
-
Peralis Tomaz, Kaira Cristina (author)
-
Neves, Bruno Junior (author)
-
Almeida, Ludimila Dias (author)
-
Bargieri, Daniel Youssef (author)
-
Lacerda, Marcus Vinicius Guimarães de (author)
-
Lemos Cravo, Pedro Vitor (author)
-
- Sunnerhagen, Per, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
-
Prudêncio, Miguel (author)
-
Andrade, Carolina Horta (author)
-
Pinto Lopes, Stefanie Costa (author)
-
Carazzolle, Marcelo Falsarella (author)
-
Tilley, Leann (author)
-
Bilsland, Elizabeth (author)
-
Borges, Júlio César (author)
-
Maranhão Costa, Fabio Trindade (author)
-
show less...
-
(creator_code:org_t)
- 2021-03-10
- 2021
- English.
-
In: ACS Infectious Diseases. - : American Chemical Society (ACS). - 2373-8227. ; 7:4, s. 759-776
- Related links:
-
https://pubs.acs.org...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Antimalarial drugs with novel modes of action and wide therapeutic potential are needed to pave the way for malaria eradication. Violacein is a natural compound known for its biological activity against cancer cells and several pathogens, including the malaria parasite, Plasmodium falciparum (Pf). Herein, using chemical genomic profiling (CGP), we found that violacein affects protein homeostasis. Mechanistically, violacein binds Pf chaperones, PfHsp90 and PfHsp70-1, compromising the latter's ATPase and chaperone activities. Additionally, violacein-treated parasites exhibited increased protein unfolding and proteasomal degradation. The uncoupling of the parasite stress response reflects the multistage growth inhibitory effect promoted by violacein. Despite evidence of proteotoxic stress, violacein did not inhibit global protein synthesis via UPR activation-a process that is highly dependent on chaperones, in agreement with the notion of a violacein-induced proteostasis collapse. Our data highlight the importance of a functioning chaperone-proteasome system for parasite development and differentiation. Thus, a violacein-like small molecule might provide a good scaffold for development of a novel probe for examining the molecular chaperone network and/or antiplasmodial drug design.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Tavella, Tatyana ...
-
da Silva, Noeli ...
-
Spillman, Natali ...
-
Kayano, Ana Caro ...
-
Cassiano, Gustav ...
-
Vasconcelos, Adr ...
-
show more...
-
Camargo, Antônio ...
-
da Silva, Djane ...
-
Fontinha, Diana
-
Salazar Alvarez, ...
-
Ferreira, Letíci ...
-
Peralis Tomaz, K ...
-
Neves, Bruno Jun ...
-
Almeida, Ludimil ...
-
Bargieri, Daniel ...
-
Lacerda, Marcus ...
-
Lemos Cravo, Ped ...
-
Sunnerhagen, Per ...
-
Prudêncio, Migue ...
-
Andrade, Carolin ...
-
Pinto Lopes, Ste ...
-
Carazzolle, Marc ...
-
Tilley, Leann
-
Bilsland, Elizab ...
-
Borges, Júlio Cé ...
-
Maranhão Costa, ...
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Biochemistry and ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Cell Biology
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Bioinformatics a ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Pharmaceutical S ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Microbiology in ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Computer and Inf ...
-
and Bioinformatics
- Articles in the publication
-
ACS Infectious D ...
- By the university
-
University of Gothenburg