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The interplay betwe...
The interplay between oxidative stress, exercise, and pain in health and disease: Potential role of autonomic regulation and epigenetic mechanisms
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Hendrix, J. (author)
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- Nijs, Jo (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering,Centrum för personcentrerad vård vid Göteborgs universitet (GPCC),Institute of Neuroscience and Physiology, Department of Health and Rehabilitation,University of Gothenburg Centre for person-centred care (GPCC)
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Ickmans, K. (author)
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Godderis, L. (author)
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Ghosh, M. (author)
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Polli, A. (author)
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(creator_code:org_t)
- 2020-11-23
- 2020
- English.
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In: Antioxidants. - : MDPI AG. - 2076-3921. ; 9:11, s. 1-25
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Abstract
Subject headings
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- Oxidative stress can be induced by various stimuli and altered in certain conditions, including exercise and pain. Although many studies have investigated oxidative stress in relation to either exercise or pain, the literature presents conflicting results. Therefore, this review critically discusses existing literature about this topic, aiming to provide a clear overview of known interactions between oxidative stress, exercise, and pain in healthy people as well as in people with chronic pain, and to highlight possible confounding factors to keep in mind when reflecting on these interactions. In addition, autonomic regulation and epigenetic mechanisms are proposed as potential mechanisms of action underlying the interplay between oxidative stress, exercise, and pain. This review highlights that the relation between oxidative stress, exercise, and pain is poorly understood and not straightforward, as it is dependent on the characteristics of exercise, but also on which population is investigated. To be able to compare studies on this topic, strict guidelines should be developed to limit the effect of several confounding factors. This way, the true interplay between oxidative stress, exercise, and pain, and the underlying mechanisms of action can be revealed and validated via independent studies. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Autonomic nervous system
- Chronic fatigue syndrome
- Chronic pain
- Epigenetics
- Exercise
- Fibromyalgia
- Oxidative stress
Publication and Content Type
- ref (subject category)
- art (subject category)
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