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The Evolution of Tr...
The Evolution of Transplantation From Saving Lives to Fertility Treatment DUETS (Dallas UtErus Transplant Study)
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Testa, G. (author)
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McKenna, G. J. (author)
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Bayer, J. (author)
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Wall, A. (author)
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Fernandez, H. (author)
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Martinez, E. (author)
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Gupta, A. (author)
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Ruiz, R. (author)
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Onaca, N. (author)
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Gunby, R. T. (author)
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Gregg, A. R. (author)
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- Olausson, Michael, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Koon, E. C. (author)
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Johannesson, L. (author)
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(creator_code:org_t)
- 2020-07-09
- 2020
- English.
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In: Annals of Surgery. - : Ovid Technologies (Wolters Kluwer Health). - 0003-4932 .- 1528-1140. ; 272:3, s. 411-417
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Abstract
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- Objective: We report the results of the first 20 uterus transplants performed in our institution. Summary Background Data: Uterus transplantation (UTx) aims at giving women affected by absolute uterine-factor infertility the possibility of carrying their own pregnancy. UTx has evolved from experimental to an established surgical procedure. Methods: The Dallas Uterus Transplant Study (DUETS) program started in 2016. The uterus was transplanted in orthotopic position with vascular anastomoses to the external iliac vessels and removed when 1 or 2 live births were achieved. Immunosuppression lasted only for the duration of the uterus graft. Results: Twenty women, median age 29.7 years, enrolled in the study, with 10 in phase 1 and 10 in phase 2. All but 2 recipients had a congenital absence of the uterus. Eighteen recipients received uteri from living donors and 2 from deceased donors. In phase 1, 50% of recipients had a technically successful uterus transplant, compared to 90% in phase 2. Four recipients with a technical success in phase 1 have delivered 1 or 2 babies, and the fifth recipient with a technical success is >30 weeks pregnant. In phase 2, 2 recipients have delivered healthy babies and 5 are pregnant. Conclusions: UTx is a unique type of transplant; whose only true success is a healthy child birth. Based on results presented here, involving refinement of the surgical technique and donor selection process, UTx is now an established solution for absolute uterine-factor infertility.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- absolute uterine-factor infertility
- living donor
- uterus
- transplantation
- deceased donor
- trial
- Surgery
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Testa, G.
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McKenna, G. J.
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Bayer, J.
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Wall, A.
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Fernandez, H.
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Martinez, E.
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show more...
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Gupta, A.
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Ruiz, R.
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Onaca, N.
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Gunby, R. T.
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Gregg, A. R.
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Olausson, Michae ...
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Koon, E. C.
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Johannesson, L.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Annals of Surger ...
- By the university
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University of Gothenburg