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Health-related qual...
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Geijer, Mats,1957University of Gothenburg,Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology,Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Radiology, Gothenburg, Sweden; Department of Clinical Sciences, Lund University, Lund, Sweden,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Radiol, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Radiol, Reg Vastra Gotaland, Gothenburg, Sweden.;Lund Univ, Dept Clin Sci, Lund, Sweden.
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Health-related quality of life in early psoriatic arthritis compared with early rheumatoid arthritis and a general population
- Article/chapterEnglish2021
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LIBRIS-ID:oai:gup.ub.gu.se/302649
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https://gup.ub.gu.se/publication/302649URI
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https://doi.org/10.1016/j.semarthrit.2020.10.010DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-186302URI
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https://lup.lub.lu.se/record/4e6ae624-0be3-4d8e-9ad8-10ca18540855URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-174410URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-439926URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Funding Agencies|Swedish Psoriasis Foundation
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Objective: Both psoriatic arthritis (PsA) and rheumatoid arthritis (RA) have a significant impact on quality of life, but few reports have compared the two diseases. The current study assessed health-related quality of life (HRQoL) in PsA at diagnosis and after five years compared with early rheumatoid arthritis (RA) and a matched general population. Methods: Patients with early PsA and early RA included in two Swedish registries with HRQoL data measured by the Medical Outcomes Study Short Form 36 (SF-36) at baseline and at five years follow-up were included. Differences in SF-36 scores compared with the general population were calculated for each patient. Physical function, disease activity, the delay before diagnosis, pain, and general wellbeing were used as explanatory variables. Statistical tests included t-tests and univariate and multivariate linear regression. Results: PsA (n = 166) and RA (n = 133) patients of both sexes had significantly reduced HRQoL at disease onset. After five years, PsA patients still had impairments in several domains of SF-36, whereas RA patients had an almost normalized HRQoL. The time from symptom onset to diagnosis, disease activity, and disability independently contributed to the reduced improvement in PsA. Conclusion: Both early PsA and RA are characterized by severely reduced HRQoL. Despite more severe disease at inclusion, normalization of HRQoL is seen in patients with RA but not PsA. This may be due to delay in the diagnosis of PsA or more powerful interventions in RA. Earlier detection, lifestyle intervention, and more aggressive management strategies may be needed for PsA. (C) 2020 Elsevier Inc. All rights reserved.
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Alenius, Gerd-Marie,Docent,1957-Umeå University,Umeå universitet,Reumatologi,Umeå Univ, Publ Hlth & Clin Med Rheumatol, SE-90185 Umeå, Sweden.;Helsinborgs Lasarett, Helsingborg, Sweden.(Swepub:umu)geal0001
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Andre, L.Helsinborgs Lasarett, Helsingborg, Sweden.,Helsingborg Hospital
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Husmark, T.Department of Rheumatology, Falu Hospital, Falun, Sweden,Falun Central Hospital,Falun Cent Hosp, Dept Rheumatol, Falun, Sweden.
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Larsson, P. T.Department of Rheumatology, Karolinska University Hospital Huddinge, Stockholm, Sweden,Karolinska Univ Hosp Huddinge, Dept Rheumatol, Stockholm, Sweden.
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Lindqvist, Ulla,1948-Uppsala universitet,Uppsala University,Uppsala Univ, Sweden,Reumatologi(Swepub:uu)ullalq
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Thyberg, IngridLinköpings universitet,Linköping University,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland,Linköping Univ, Dept & Clin & Expt Med, Dept Rheumatol, Linköping, Sweden.(Swepub:liu)ingth40
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Theander, ElkeLund University,Lunds universitet,Reumatologi,Forskargrupper vid Lunds universitet,Rheumatology,Lund University Research Groups,Skåne University Hospital,Skane Univ Hosp, Dept Rheumatol, Malmö, Sweden.;Lund Univ, Malmö, Sweden.(Swepub:lu)medf-eth
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Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för radiologi
(creator_code:org_t)
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In:Seminars in Arthritis and Rheumatism: Elsevier BV51:1, s. 246-2520049-01721532-866X
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