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- Escartin, C. (author)
Reactive astrocyte nomenclature, definitions, and future directions
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- 2021-02-15
- Springer Science and Business Media LLC,2021
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/302677
- https://gup.ub.gu.se/publication/302677URI
- https://doi.org/10.1038/s41593-020-00783-4DOI
Supplementary language notes
- Language:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters-preferably in vivo-plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions. Good-bad binary classifications fail to describe reactive astrocytes in CNS disorders. Here, 81 researchers reach consensus on widespread misconceptions and provide definitions and recommendations for future research on reactive astrocytes.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
- Neurosciences & Neurology
Added entries (persons, corporate bodies, meetings, titles ...)
- Galea, E. (author)
- Lakatos, A. (author)
- O'Callaghan, J. P. (author)
- Petzold, G. C. (author)
- Serrano-Pozo, A. (author)
- Steinhauser, C. (author)
- Volterra, A. (author)
- Carmignoto, G. (author)
- Agarwal, A. (author)
- Allen, N. J. (author)
- Araque, A. (author)
- Barbeito, L. (author)
- Barzilai, A. (author)
- Bergles, D. E. (author)
- Bonvento, G. (author)
- Butt, A. M. (author)
- Chen, W. T. (author)
- Cohen-Salmon, M. (author)
- Cunningham, C. (author)
- Deneen, B. (author)
- De Strooper, B. (author)
- Diaz-Castro, B. (author)
- Farina, C. (author)
- Freeman, M. (author)
- Gallo, V. (author)
- Goldman, J. E. (author)
- Goldman, S. A. (author)
- Gotz, M. (author)
- Gutierrez, A. (author)
- Haydon, P. G. (author)
- Heiland, D. H. (author)
- Hol, E. M. (author)
- Holt, M. G. (author)
- Iino, M. (author)
- Kastanenka, K. V. (author)
- Kettenmann, H. (author)
- Khakh, B. S. (author)
- Koizumi, S. (author)
- Lee, C. J. (author)
- Liddelow, S. A. (author)
- MacVicar, B. A. (author)
- Magistretti, P. (author)
- Messing, A. (author)
- Mishra, A. (author)
- Molofsky, A. V. (author)
- Murai, K. K. (author)
- Norris, C. M. (author)
- Okada, S. (author)
- Oliet, S. H. R. (author)
- Oliveira, J. F. (author)
- Panatier, A. (author)
- Parpura, V. (author)
- Pekna, Marcela,1966Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xpekma (author)
- Pekny, Milos,1965Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xpekmi (author)
- Pellerin, L. (author)
- Perea, G. (author)
- Perez-Nievas, B. G. (author)
- Pfrieger, F. W. (author)
- Poskanzer, K. E. (author)
- Quintana, F. J. (author)
- Ransohoff, R. M. (author)
- Riquelme-Perez, M. (author)
- Robel, S. (author)
- Rose, C. R. (author)
- Rothstein, J. D. (author)
- Rouach, N. (author)
- Rowitch, D. H. (author)
- Semyanov, A. (author)
- Sirko, S. (author)
- Sontheimer, H. (author)
- Swanson, R. A. (author)
- Vitorica, J. (author)
- Wanner, I. B. (author)
- Wood, L. B. (author)
- Wu, J. Q. (author)
- Zheng, B. H. (author)
- Zimmer, E. R. (author)
- Zorec, R. (author)
- Sofroniew, M. V. (author)
- Verkhratsky, A. (author)
- Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap (creator_code:org_t)
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- In:Nature Neuroscience: Springer Science and Business Media LLC24, s. 312-3251097-62561546-1726
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- Steinhauser, C.
- Volterra, A.
- Carmignoto, G.
- Agarwal, A.
- Allen, N. J.
- Araque, A.
- Barbeito, L.
- Barzilai, A.
- Bergles, D. E.
- Bonvento, G.
- Butt, A. M.
- Chen, W. T.
- Cohen-Salmon, M.
- Cunningham, C.
- Deneen, B.
- De Strooper, B.
- Diaz-Castro, B.
- Farina, C.
- Freeman, M.
- Gallo, V.
- Goldman, J. E.
- Goldman, S. A.
- Gotz, M.
- Gutierrez, A.
- Haydon, P. G.
- Heiland, D. H.
- Hol, E. M.
- Holt, M. G.
- Iino, M.
- Kastanenka, K. V ...
- Kettenmann, H.
- Khakh, B. S.
- Koizumi, S.
- Lee, C. J.
- Liddelow, S. A.
- MacVicar, B. A.
- Magistretti, P.
- Messing, A.
- Mishra, A.
- Molofsky, A. V.
- Murai, K. K.
- Norris, C. M.
- Okada, S.
- Oliet, S. H. R.
- Oliveira, J. F.
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- Pekny, Milos, 19 ...
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- Swanson, R. A.
- Vitorica, J.
- Wanner, I. B.
- Wood, L. B.
- Wu, J. Q.
- Zheng, B. H.
- Zimmer, E. R.
- Zorec, R.
- Sofroniew, M. V.
- Verkhratsky, A.
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