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Role of dopamine an...
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Garzón, BenjamínKarolinska Institutet
(author)
Role of dopamine and gray matter density in aging effects and individual differences of functional connectomes
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-01-09
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Springer Science and Business Media LLC,2021
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/302924
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https://gup.ub.gu.se/publication/302924URI
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https://doi.org/10.1007/s00429-020-02205-4DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-179505URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:145631769URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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With increasing age, functional connectomes become dissimilar across normal individuals, reflecting heterogenous aging effects on functional connectivity (FC). We investigated the distribution of these effects across the connectome and their relationship with age-related differences in dopamine (DA) D1 receptor availability and gray matter density (GMD). With this aim, we determined aging effects on mean and interindividual variance of FC using fMRI in 30 younger and 30 older healthy subjects and mapped the contribution of each connection to the patterns of age-related similarity loss. Aging effects on mean FC accounted mainly for the dissimilarity between connectomes of younger and older adults, and were related, across brain regions, to aging effects on DA D1 receptor availability. Aging effects on the variance of FC indicated a global increase in variance with advancing age, explained connectome dissimilarity among older subjects and were related to aging effects on variance of GMD. The relationship between aging and the similarity of connectomes can thus be partly explained by age differences in DA modulation and gray matter structure.
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Lövdén, Martin,1972Karolinska Institutet,Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology(Swepub:gu)xlovma
(author)
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de Boer, Lieke
(author)
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Axelsson, Jan,1966-Umeå universitet,Radiofysik,Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)jaax0004
(author)
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Riklund, Katrine,MD, PhD, Professor,1963-Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)kaah0001
(author)
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Bäckman, LarsKarolinska Institutet
(author)
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Nyberg, Lars,1966-Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI),Fysiologi(Swepub:umu)lany0001
(author)
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Guitart-Masip, MarcKarolinska Institutet
(author)
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Karolinska InstitutetPsykologiska institutionen
(creator_code:org_t)
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In:Brain Structure and Function: Springer Science and Business Media LLC226, s. 743-7581863-26531863-2661
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Garzón, Benjamín
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Lövdén, Martin, ...
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de Boer, Lieke
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Axelsson, Jan, 1 ...
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Riklund, Katrine ...
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Bäckman, Lars
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Nyberg, Lars, 19 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
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Brain Structure ...
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University of Gothenburg
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Umeå University
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Karolinska Institutet