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Role of dopamine an...
Role of dopamine and gray matter density in aging effects and individual differences of functional connectomes
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- Garzón, Benjamín (author)
- Karolinska Institutet
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- Lövdén, Martin, 1972 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology
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de Boer, Lieke (author)
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- Axelsson, Jan, 1966- (author)
- Umeå universitet,Radiofysik,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Riklund, Katrine, MD, PhD, Professor, 1963- (author)
- Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Bäckman, Lars (author)
- Karolinska Institutet
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- Nyberg, Lars, 1966- (author)
- Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI),Fysiologi
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- Guitart-Masip, Marc (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-01-09
- 2021
- English.
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In: Brain Structure and Function. - : Springer Science and Business Media LLC. - 1863-2653 .- 1863-2661. ; 226, s. 743-758
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- With increasing age, functional connectomes become dissimilar across normal individuals, reflecting heterogenous aging effects on functional connectivity (FC). We investigated the distribution of these effects across the connectome and their relationship with age-related differences in dopamine (DA) D1 receptor availability and gray matter density (GMD). With this aim, we determined aging effects on mean and interindividual variance of FC using fMRI in 30 younger and 30 older healthy subjects and mapped the contribution of each connection to the patterns of age-related similarity loss. Aging effects on mean FC accounted mainly for the dissimilarity between connectomes of younger and older adults, and were related, across brain regions, to aging effects on DA D1 receptor availability. Aging effects on the variance of FC indicated a global increase in variance with advancing age, explained connectome dissimilarity among older subjects and were related to aging effects on variance of GMD. The relationship between aging and the similarity of connectomes can thus be partly explained by age differences in DA modulation and gray matter structure.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Keyword
- Aging
- Dopamine
- fMRI
- Functional connectome
- PET
- Dopamine
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Garzón, Benjamín
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Lövdén, Martin, ...
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de Boer, Lieke
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Axelsson, Jan, 1 ...
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Riklund, Katrine ...
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Bäckman, Lars
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show more...
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Nyberg, Lars, 19 ...
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Guitart-Masip, M ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
- Articles in the publication
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Brain Structure ...
- By the university
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University of Gothenburg
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Umeå University
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Karolinska Institutet