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Comparison of CSF neurofilament light chain, neurogranin, and tau to MRI markers

Mielke, M. M. (author)
Przybelski, S. A. (author)
Lesnick, T. G. (author)
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Kern, Silke (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
Zetterberg, Henrik, 1973 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Blennow, Kaj, 1958 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Knopman, D. S. (author)
Graff-Radford, J. (author)
Petersen, R. C. (author)
Jack, C. R. (author)
Vemuri, P. (author)
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 (creator_code:org_t)
2021-03-04
2021
English.
In: Alzheimers & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 17:5, s. 801-812
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Introduction We determined whether cerebrospinal fluid (CSF) neurofilament light (NfL), neurogranin (Ng), and total-tau (t-tau) differentially mapped to magnetic resonance imaging (MRI) measures of cortical thickness, microstructural integrity (corpus callosum and cingulum fractional anisotropy [FA]), and white matter hyperintensities (WMH). Methods Analyses included 536 non-demented Mayo Clinic Study of Aging participants with CSF NfL, Ng, t-tau, amyloid beta (A beta)42 and longitudinal MRI scans. Linear mixed models assessed longitudinal associations between CSF markers and MRI changes. Results Higher CSF NfL was associated with decreasing microstructural integrity and WMH. Higher t-tau was associated with decreasing temporal lobe and Alzheimer's disease (AD) meta region of interest (ROI) cortical thickness. There was no association between Ng and any MRI measure. CSF A beta 42 interacted with Ng for declines in temporal lobe and AD meta ROI cortical thickness and cingulum FA. Discussion CSF NfL predicts changes in white matter integrity, t-tau reflects non-specific changes in cortical thickness, and Ng reflects AD-specific synaptic and neuronal degeneration.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Keyword

Alzheimer's
amyloid
cohort study
cortical thickness
cerebrospinal
fluid
magnetic resonance imaging
neurodegeneration
neurofilament
light chain
neurogranin
total tau
white matter integrity
Neurosciences & Neurology

Publication and Content Type

ref (subject category)
art (subject category)

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