SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:gup.ub.gu.se/303463"
 

Search: onr:"swepub:oai:gup.ub.gu.se/303463" > Plasma P-tau181 to ...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Chong, Joyce R (author)

Plasma P-tau181 to Aβ42 ratio is associated with brain amyloid burden and hippocampal atrophy in an Asian cohort of Alzheimer's disease patients with concomitant cerebrovascular disease.

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-03-31
  • Wiley,2021

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/303463
  • https://gup.ub.gu.se/publication/303463URI
  • https://doi.org/10.1002/alz.12332DOI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • There is increasing evidence that phosphorylated tau (P-tau181) is a specific biomarker for Alzheimer's disease (AD) pathology, but its potential utility in non-White patient cohorts and patients with concomitant cerebrovascular disease (CeVD) is unknown.Single molecule array (Simoa) measurements of plasma P-tau181, total tau, amyloid beta (Aβ)40 and Aβ42, as well as derived ratios were correlated with neuroimaging modalities indicating brain amyloid (Aβ+), hippocampal atrophy, and CeVD in a Singapore-based cohort of non-cognitively impaired (NCI; n=43), cognitively impaired no dementia (CIND; n=91), AD (n=44), and vascular dementia (VaD; n=22) subjects.P-tau181/Aβ42 ratio showed the highest area under the curve (AUC) for Aβ+ (AUC=0.889) and for discriminating between AD Aβ+ and VaD Aβ- subjects (AUC=0.903). In addition, P-tau181/Aβ42 ratio was associated with hippocampal atrophy. None of the biomarkers was associated with CeVD.Plasma P-tau181/Aβ42 ratio may be a noninvasive means of identifying AD with elevated brain amyloid in populations with concomitant CeVD.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ashton, Nicholas J.Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xashtn (author)
  • Karikari, ThomasGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xkarit (author)
  • Tanaka, Tomotaka (author)
  • Saridin, Francis N (author)
  • Reilhac, Anthonin (author)
  • Robins, Edward G (author)
  • Nai, Ying-Hwey (author)
  • Vrooman, Henri (author)
  • Hilal, Saima (author)
  • Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
  • Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
  • Lai, Mitchell K P (author)
  • Chen, Christopher P (author)
  • Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

Related titles

  • In:Alzheimer's & dementia : the journal of the Alzheimer's Association: Wiley17:10, s. 1649-16621552-5279
  • In:Alzheimer's & Dementia: Wiley17:10, s. 1649-16621552-5260

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view