Search: onr:"swepub:oai:gup.ub.gu.se/303463" >
Plasma P-tau181 to ...
Plasma P-tau181 to Aβ42 ratio is associated with brain amyloid burden and hippocampal atrophy in an Asian cohort of Alzheimer's disease patients with concomitant cerebrovascular disease.
- Article/chapterEnglish2021
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/303463
-
https://gup.ub.gu.se/publication/303463URI
-
https://doi.org/10.1002/alz.12332DOI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
There is increasing evidence that phosphorylated tau (P-tau181) is a specific biomarker for Alzheimer's disease (AD) pathology, but its potential utility in non-White patient cohorts and patients with concomitant cerebrovascular disease (CeVD) is unknown.Single molecule array (Simoa) measurements of plasma P-tau181, total tau, amyloid beta (Aβ)40 and Aβ42, as well as derived ratios were correlated with neuroimaging modalities indicating brain amyloid (Aβ+), hippocampal atrophy, and CeVD in a Singapore-based cohort of non-cognitively impaired (NCI; n=43), cognitively impaired no dementia (CIND; n=91), AD (n=44), and vascular dementia (VaD; n=22) subjects.P-tau181/Aβ42 ratio showed the highest area under the curve (AUC) for Aβ+ (AUC=0.889) and for discriminating between AD Aβ+ and VaD Aβ- subjects (AUC=0.903). In addition, P-tau181/Aβ42 ratio was associated with hippocampal atrophy. None of the biomarkers was associated with CeVD.Plasma P-tau181/Aβ42 ratio may be a noninvasive means of identifying AD with elevated brain amyloid in populations with concomitant CeVD.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Ashton, Nicholas J.Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xashtn
(author)
-
Karikari, ThomasGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xkarit
(author)
-
Tanaka, Tomotaka
(author)
-
Saridin, Francis N
(author)
-
Reilhac, Anthonin
(author)
-
Robins, Edward G
(author)
-
Nai, Ying-Hwey
(author)
-
Vrooman, Henri
(author)
-
Hilal, Saima
(author)
-
Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
(author)
-
Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(author)
-
Lai, Mitchell K P
(author)
-
Chen, Christopher P
(author)
-
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
Related titles
-
In:Alzheimer's & dementia : the journal of the Alzheimer's Association: Wiley17:10, s. 1649-16621552-5279
-
In:Alzheimer's & Dementia: Wiley17:10, s. 1649-16621552-5260
Internet link
Find in a library
To the university's database
- By the author/editor
-
Chong, Joyce R
-
Ashton, Nicholas ...
-
Karikari, Thomas
-
Tanaka, Tomotaka
-
Saridin, Francis ...
-
Reilhac, Anthoni ...
-
show more...
-
Robins, Edward G
-
Nai, Ying-Hwey
-
Vrooman, Henri
-
Hilal, Saima
-
Zetterberg, Henr ...
-
Blennow, Kaj, 19 ...
-
Lai, Mitchell K ...
-
Chen, Christophe ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Alzheimer's & de ...
-
Alzheimer's & De ...
- By the university
-
University of Gothenburg