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SARS-CoV-2 encephal...
SARS-CoV-2 encephalitis is a cytokine release syndrome: evidences from cerebrospinal fluid analyses.
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Pilotto, Andrea (author)
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Masciocchi, Stefano (author)
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Volonghi, Irene (author)
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De Giuli, Valeria (author)
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Caprioli, Francesca (author)
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Mariotto, Sara (author)
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Ferrari, Sergio (author)
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Bozzetti, Silvia (author)
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Imarisio, Alberto (author)
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Risi, Barbara (author)
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Premi, Enrico (author)
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Benussi, Alberto (author)
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Focà, Emanuele (author)
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Castelli, Francesco (author)
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Zanusso, Gianluigi (author)
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Monaco, Salvatore (author)
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Stefanelli, Paola (author)
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Gasparotti, Roberto (author)
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Zekeridou, Anastasia (author)
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McKeon, Andrew (author)
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- Ashton, Nicholas J. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Padovani, Alessandro (author)
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(creator_code:org_t)
- 2021-01-04
- 2021
- English.
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In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. - : Oxford University Press (OUP). - 1537-6591. ; 73:9
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Abstract
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- Recent findings indicated that SARS-CoV-2 related neurological manifestations involve cytokine release syndrome along with endothelial activation, blood brain barrier dysfunction, and immune-mediated mechanisms. Very few studies have fully investigated the CSF correlates of SARS-CoV-2 encephalitis.Patients with PCR-confirmed SARS-CoV-2 infection and encephalitis (COV-Enc), encephalitis without SARS-CoV-2 infection (ENC) and healthy controls (HC) underwent an extended panel of CSF neuronal (NfL, T-tau), glial (GFAP, TREM2, YKL-40) and inflammatory biomarkers (IL-1β, IL-6, Il-8, TNF- α, CXCL-13 and β2-microglobulin).Thirteen COV-Enc, 21 ENC and 18 HC entered the study. In COV-Enc cases, CSF was negative for SARS-CoV-2 real-time PCR but exhibited increased IL-8 levels independently from presence of pleocytosis/hyperproteinorracchia. COV-Enc patients showed increased IL-6, TNF- α, and β2-microglobulin and glial markers (GFAP, sTREM-2, YKL-40) levels similar to ENC but normal CXCL13 levels. Neuronal markers NfL and T-Tau were abnormal only in severe cases.SARS-CoV-2-related encephalitis were associated with prominent glial activation and neuroinflammatory markers, whereas neuronal markers were increased in severe cases only. The pattern of CSF alterations suggested a cytokine-release syndrome as the main inflammatory mechanism of SARS-CoV-2 related encephalitis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Pilotto, Andrea
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Masciocchi, Stef ...
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Volonghi, Irene
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De Giuli, Valeri ...
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Caprioli, France ...
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Mariotto, Sara
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show more...
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Ferrari, Sergio
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Bozzetti, Silvia
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Imarisio, Albert ...
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Risi, Barbara
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Premi, Enrico
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Benussi, Alberto
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Focà, Emanuele
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Castelli, France ...
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Zanusso, Gianlui ...
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Monaco, Salvator ...
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Stefanelli, Paol ...
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Gasparotti, Robe ...
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Zekeridou, Anast ...
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McKeon, Andrew
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Ashton, Nicholas ...
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Padovani, Alessa ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Clinical infecti ...
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Clinical Infecti ...
- By the university
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University of Gothenburg