An examination of a novel multipanel of CSF biomarkers in the Alzheimer's disease clinical and pathological continuum.

Van Hulle, Carol (author)

Jonaitis, Erin M (author)

Betthauser, Tobey J (author)

Batrla, Richard (author)

Wild, Norbert (author)

Kollmorgen, Gwendlyn (author)

Andreasson, Ulf, 1968 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Okonkwo, Ozioma (author)

Bendlin, Barbara B (author)

Asthana, Sanjay (author)

Carlsson, Cynthia M (author)

Johnson, Sterling C (author)

Zetterberg, Henrik, 1973 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Blennow, Kaj, 1958 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

(creator_code:org_t)

2020-12-18
2021
English.
In: Alzheimer's & dementia : the journal of the Alzheimer's Association. - : Wiley. - 1552-5279. ; 17:3, s. 431-445

Related links:: https://onlinelibrar...; show more...; https://gup.ub.gu.se...; https://doi.org/10.1...; show less...

Abstract Subject headings

This study examines the utility of a multipanel of cerebrospinal fluid (CSF) biomarkers complementing Alzheimer's disease (AD) biomarkers in a clinical research sample. We compared biomarkers across groups defined by clinical diagnosis and pTau181 /Aβ42 status (+/-) and explored their value in predicting cognition.CSF biomarkers amyloid beta (Aβ)42 , pTau181 , tTau, Aβ40 , neurogranin, neurofilament light (NfL), α-synuclein, glial fibrillary acidic protein (GFAP), chitinase-3-like protein 1 (YKL-40), soluble triggering receptor expressed on myeloid cells 2 (sTREM2), S100 calcium binding protein B (S100B), and interleukin 6 (IL6), were measured with the NeuroToolKit (NTK) for 720 adults ages 40 to 93 years (mean age=63.9 years, standard deviation [SD]=9.0; 50 with dementia; 54 with mild cognitive impairment [MCI], 616 unimpaired).Neurodegeneration and glial activation biomarkers were elevated in pTau181 /Aβ42 + MCI/dementia participants relative to all pTau181 /Aβ42 - participants. Neurodegeneration biomarkers increased with clinical severity among pTau181 /Aβ42 + participants and predicted worse cognitive performance. Glial activation biomarkers were unrelated to cognitive performance.The NTK contains promising markers that improve the pathophysiological characterization of AD. Neurodegeneration biomarkers beyond tTau improved statistical prediction of cognition and disease stages.

By the author/editor: Van Hulle, Carol; Jonaitis, Erin M; Betthauser, Tobe ...; Batrla, Richard; Wild, Norbert; Kollmorgen, Gwen ...; show more...; Andreasson, Ulf, ...; Okonkwo, Ozioma; Bendlin, Barbara ...; Asthana, Sanjay; Carlsson, Cynthi ...; Johnson, Sterlin ...; Zetterberg, Henr ...; Blennow, Kaj, 19 ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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