Search: onr:"swepub:oai:gup.ub.gu.se/303594" >
Application of the ...
Application of the ATN classification scheme in a population without dementia: Findings from the EPAD cohort.
-
Ingala, Silvia (author)
-
De Boer, Casper (author)
-
Masselink, Larissa A (author)
-
show more...
-
Vergari, Ilaria (author)
-
Lorenzini, Luigi (author)
-
- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
Chételat, Gaël (author)
-
Di Perri, Carol (author)
-
Ewers, Michael (author)
-
van der Flier, Wiesje M (author)
-
Fox, Nick C (author)
-
Gispert, Juan Domingo (author)
-
Haller, Sven (author)
-
Molinuevo, José Luís (author)
-
Muniz-Terrera, Graciela (author)
-
Mutsaerts, Henri Jmm (author)
-
Ritchie, Craig W (author)
-
Ritchie, Karen (author)
-
Schmidt, Mark (author)
-
Schwarz, Adam J (author)
-
Vermunt, Lisa (author)
-
Waldman, Adam D (author)
-
Wardlaw, Joanna (author)
-
Wink, Alle Meije (author)
-
Wolz, Robin (author)
-
Wottschel, Viktor (author)
-
Scheltens, Philip (author)
-
- Visser, Pieter Jelle (author)
- Karolinska Institutet
-
Barkhof, Frederik (author)
-
show less...
-
(creator_code:org_t)
- 2021-04-03
- 2021
- English.
-
In: Alzheimer's & dementia : the journal of the Alzheimer's Association. - : Wiley. - 1552-5279. ; 17:7, s. 1189-1204
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- We classified non-demented European Prevention of Alzheimer's Dementia (EPAD) participants through the amyloid/tau/neurodegeneration (ATN) scheme and assessed their neuropsychological and imaging profiles.From 1500 EPAD participants, 312 were excluded. Cerebrospinal fluid cut-offs of 1000 pg/mL for amyloid beta (Aß)1-42 and 27 pg/mL for p-tau181 were validated using Gaussian mixture models. Given strong correlation of p-tau and t-tau (R2 =0.98, P<0.001), neurodegeneration was defined by age-adjusted hippocampal volume. Multinomial regressions were used to test whether neuropsychological tests and regional brain volumes could distinguish ATN stages.Age was 65 ± 7 years, with 58% females and 38% apolipoprotein E (APOE) ε4 carriers; 57.1% were A-T-N-, 32.5% were in the Alzheimer's disease (AD) continuum, and 10.4% suspected non-Alzheimer's pathology. Age and cerebrovascular burden progressed with biomarker positivity (P<0.001). Cognitive dysfunction appeared with T+. Paradoxically higher regional gray matter volumes were observed in A+T-N- compared to A-T-N- (P<0.001).In non-demented individuals along the AD continuum, p-tau drives cognitive dysfunction. Memory and language domains are affected in the earliest stages.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Ingala, Silvia
-
De Boer, Casper
-
Masselink, Laris ...
-
Vergari, Ilaria
-
Lorenzini, Luigi
-
Blennow, Kaj, 19 ...
-
show more...
-
Chételat, Gaël
-
Di Perri, Carol
-
Ewers, Michael
-
van der Flier, W ...
-
Fox, Nick C
-
Gispert, Juan Do ...
-
Haller, Sven
-
Molinuevo, José ...
-
Muniz-Terrera, G ...
-
Mutsaerts, Henri ...
-
Ritchie, Craig W
-
Ritchie, Karen
-
Schmidt, Mark
-
Schwarz, Adam J
-
Vermunt, Lisa
-
Waldman, Adam D
-
Wardlaw, Joanna
-
Wink, Alle Meije
-
Wolz, Robin
-
Wottschel, Vikto ...
-
Scheltens, Phili ...
-
Visser, Pieter J ...
-
Barkhof, Frederi ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Alzheimer's & de ...
-
Alzheimer's & De ...
- By the university
-
University of Gothenburg
-
Karolinska Institutet