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  • Hagman, A.Karolinska Institute,Karolinska University Hospital,Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med Surg & Pelv Canc, S-17176 Stockholm, Sweden.;Karolinska Univ Hosp, Eugeniavagen 3, S-17176 Solna, Sweden. (author)

Urinary continence recovery and oncological outcomes after surgery for prostate cancer analysed by risk category: results from the LAParoscopic prostatectomy robot and open trial

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-03-20
  • Springer Science and Business Media LLC,2021

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  • LIBRIS-ID:oai:gup.ub.gu.se/304051
  • https://gup.ub.gu.se/publication/304051URI
  • https://doi.org/10.1007/s00345-021-03662-0DOI
  • https://lup.lub.lu.se/record/58b3be32-2c57-42dc-b2c5-32f8b4f358b7URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-469871URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:146190221URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Purpose To evaluate urinary continence (UC) recovery and oncological outcomes in different risk-groups after robot-assisted radical prostatectomy (RALP) and open retropubic radical prostatectomy (RRP). Patients and methods We analysed 2650 men with prostate cancer from seven open (n = 805) and seven robotic (n = 1845) Swedish centres between 2008 and 2011 in a prospective non-randomised trial, LAPPRO. UC recovery was defined as change of pads less than once in 24 h. Information was collected through validated questionnaires. Rate of positive surgical margins (PSM) and biochemical recurrence (BCR), defined as prostate-specific antigen (PSA) > 0.25 mg/ml, were recorded. We stratified patients into two risk groups (low-intermediate and high risk) based on the D'Amico risk classification system. Result Among men with high-risk prostate cancer, we found significantly higher rates of UC recovery up to 24 months after RRP compared to RALP (66.1% vs 60.5%) RR 0.85 (CI 95% 0.73-0.99) while PSM was more frequent after RRP compared to RALP (46.8% vs 23.5%) RR 1.56 (CI 95% 1.10-2.21). In the same group no significant difference was seen in BCR. Overall, however, BCR was significantly more common after RRP compared to RALP at 24 months (9.8% vs 6.6%) RR 1.43 (Cl 95% 1.08-1.89). The limitations of this study are its non-randomized design and the relatively short time of follow-up. Conclusions Our study indicates that men with high-risk tumour operated with open surgery had better urinary continence recovery but with a higher risk of PSM than after robotic-assisted laparoscopic surgery. No significant difference was seen in biochemical recurrence.

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  • Lantz, A.Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med Surg & Pelv Canc, S-17176 Stockholm, Sweden.;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. (author)
  • Carlsson, S.Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med Surg & Pelv Canc, S-17176 Stockholm, Sweden. (author)
  • Höijer, JonasUppsala universitet,Uppsala University,Ortopedi(Swepub:uu)jonho616 (author)
  • Stranne, Johan,1970University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology,Sahlgrenska University Hospital,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Urol, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Urol, Gothenburg, Region Vastra G, Sweden.(Swepub:gu)xstraj (author)
  • Tyritzis, S. I.Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med Surg & Pelv Canc, S-17176 Stockholm, Sweden. (author)
  • Haglind, Eva,1947University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Sahlgrenska University Hospital,Univ Gothenburg, Scandinavian Surg Outcomes Res Grp, Sahlgrenska Acad, Dept Surg,Inst Clin Sci, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Surg, Gothenburg, Region Vastra G, Sweden.(Swepub:gu)xhagev (author)
  • Bjartell, AndersLund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urological cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Urol, Lund, Sweden.(Swepub:lu)kir-abj (author)
  • Hugosson, Jonas,1955University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Urol, Gothenburg, Sweden.(Swepub:gu)xhugjo (author)
  • Akre, O.Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med Surg & Pelv Canc, S-17176 Stockholm, Sweden. (author)
  • Steineck, Gunnar,1952Karolinska Institute,University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Div Clin Canc Epidemiol,Dept Oncol, Gothenburg, Sweden.;Karolinska Inst, Div Clin Canc Epidemiol, Dept Pathol & Oncol, Stockholm, Sweden.(Swepub:gu)xstegu (author)
  • Wiklund, P.Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Icahn School of Medicine at Mount Sinai,Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med Surg & Pelv Canc, S-17176 Stockholm, Sweden.;Icahn Sch Med, Mt Sinai Hlth Syst, New York, NY USA. (author)
  • Karolinska InstituteKarolinska University Hospital (creator_code:org_t)

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  • In:World Journal of Urology: Springer Science and Business Media LLC39:9, s. 3239-32490724-49831433-8726

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