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Association between...
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McWhinney, Sean R
(author)
Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals.
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-04-16
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Springer Science and Business Media LLC,2021
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/304287
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https://gup.ub.gu.se/publication/304287URI
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https://doi.org/10.1038/s41380-021-01098-xDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:146459691URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41% of the association between BD and ventricular volume was mediatedby BMI (Z=2.73, p=0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. Future prospective brain imaging studies should investigate whether obesity could be a modifiable risk factor for neuroprogression.
Subject headings and genre
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Abé, ChristophKarolinska Institutet
(author)
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Alda, Martin
(author)
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Benedetti, Francesco
(author)
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Bøen, Erlend
(author)
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Del Mar Bonnin, Caterina
(author)
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Borgers, Tiana
(author)
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Brosch, Katharina
(author)
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Canales-Rodríguez, Erick J
(author)
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Cannon, Dara M
(author)
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Dannlowski, Udo
(author)
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Díaz-Zuluaga, Ana M
(author)
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Elvsåshagen, Torbjørn
(author)
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Eyler, Lisa T
(author)
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Fullerton, Janice M
(author)
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Goikolea, Jose M
(author)
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Goltermann, Janik
(author)
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Grotegerd, Dominik
(author)
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Haarman, Bartholomeus C M
(author)
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Hahn, Tim
(author)
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Howells, Fleur M
(author)
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Ingvar, MartinKarolinska Institutet
(author)
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Kircher, Tilo T J
(author)
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Krug, Axel
(author)
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Kuplicki, Rayus T
(author)
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Landén, Mikael,1966Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xlandt
(author)
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Lemke, Hannah
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Liberg, Benny
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Lopez-Jaramillo, Carlos
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Malt, Ulrik F
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Martyn, Fiona M
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Mazza, Elena
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McDonald, Colm
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McPhilemy, Genevieve
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Meier, Sandra
(author)
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Meinert, Susanne
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Meller, Tina
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Melloni, Elisa M T
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Mitchell, Philip B
(author)
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Nabulsi, Leila
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Nenadic, Igor
(author)
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Opel, Nils
(author)
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Ophoff, Roel A
(author)
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Overs, Bronwyn J
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Pfarr, Julia-Katharina
(author)
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Pineda-Zapata, Julian A
(author)
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Pomarol-Clotet, Edith
(author)
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Raduà, JoaquimKarolinska Institutet
(author)
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Repple, Jonathan
(author)
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Richter, Maike
(author)
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Ringwald, Kai G
(author)
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Roberts, Gloria
(author)
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Salvador, Raymond
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Savitz, Jonathan
(author)
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Schmitt, Simon
(author)
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Schofield, Peter R
(author)
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Sim, Kang
(author)
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Stein, Dan J
(author)
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Stein, Frederike
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Temmingh, Henk S
(author)
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Thiel, Katharina
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van Haren, Neeltje E M
(author)
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Gestel, Holly Van
(author)
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Vargas, Cristian
(author)
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Vieta, Eduard
(author)
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Vreeker, Annabel
(author)
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Waltemate, Lena
(author)
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Yatham, Lakshmi N
(author)
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Ching, Christopher R K
(author)
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Andreassen, Ole
(author)
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Thompson, Paul M
(author)
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Hajek, Tomas
(author)
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Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
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In:Molecular psychiatry: Springer Science and Business Media LLC26:11, s. 6806-68191476-55781359-4184
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McWhinney, Sean ...
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Abé, Christoph
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Alda, Martin
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Benedetti, Franc ...
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Bøen, Erlend
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Del Mar Bonnin, ...
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Borgers, Tiana
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Brosch, Katharin ...
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Canales-Rodrígue ...
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Cannon, Dara M
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Dannlowski, Udo
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Díaz-Zuluaga, An ...
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Elvsåshagen, Tor ...
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Eyler, Lisa T
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Fullerton, Janic ...
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Goikolea, Jose M
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Goltermann, Jani ...
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Grotegerd, Domin ...
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Haarman, Barthol ...
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Hahn, Tim
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Howells, Fleur M
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Ingvar, Martin
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Kircher, Tilo T ...
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Krug, Axel
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Kuplicki, Rayus ...
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Landén, Mikael, ...
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Lemke, Hannah
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Liberg, Benny
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Lopez-Jaramillo, ...
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Malt, Ulrik F
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Martyn, Fiona M
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Mazza, Elena
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McDonald, Colm
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McPhilemy, Genev ...
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Meier, Sandra
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Meinert, Susanne
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Meller, Tina
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Melloni, Elisa M ...
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Mitchell, Philip ...
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Nabulsi, Leila
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Nenadic, Igor
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Opel, Nils
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Ophoff, Roel A
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Overs, Bronwyn J
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Pfarr, Julia-Kat ...
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Pineda-Zapata, J ...
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Pomarol-Clotet, ...
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Raduà, Joaquim
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Repple, Jonathan
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Richter, Maike
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Ringwald, Kai G
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Roberts, Gloria
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Salvador, Raymon ...
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Savitz, Jonathan
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Schmitt, Simon
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Schofield, Peter ...
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Sim, Kang
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Stein, Dan J
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Stein, Frederike
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Temmingh, Henk S
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Thiel, Katharina
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van Haren, Neelt ...
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Gestel, Holly Va ...
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Vargas, Cristian
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Vieta, Eduard
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Vreeker, Annabel
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Waltemate, Lena
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Yatham, Lakshmi ...
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Ching, Christoph ...
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Andreassen, Ole
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Thompson, Paul M
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Hajek, Tomas
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Molecular psychi ...
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University of Gothenburg
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Karolinska Institutet