Search: onr:"swepub:oai:gup.ub.gu.se/304341" >
Neurobiology of alc...
Neurobiology of alcohol seeking behavior
-
- Domi, Esi (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten
-
- Domi, Ana, 1990 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Univ Gothenburg, Sweden
-
- Adermark, Louise, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Univ Gothenburg, Sweden
-
show more...
-
- Heilig, Markus (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken i Linköping
-
- Augier, Eric (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten
-
show less...
-
(creator_code:org_t)
- 2021-04-08
- 2021
- English.
-
In: Journal of Neurochemistry. - : Wiley. - 0022-3042 .- 1471-4159. ; 157:5, s. 1585-1614
- Related links:
-
https://onlinelibrar...
-
show more...
-
https://liu.diva-por... (primary) (Raw object)
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Alcohol addiction is a chronic relapsing brain disease characterized by an impaired ability to stop or control alcohol use despite adverse consequences. A main challenge of addiction treatment is to prevent relapse, which occurs in more than >50% of newly abstinent patients with alcohol disorder within 3 months. In people suffering from alcohol addiction, stressful events, drug-associated cues and contexts, or re-exposure to a small amount of alcohol trigger a chain of behaviors that frequently culminates in relapse. In this review, we first present the preclinical models that were developed for the study of alcohol seeking behavior, namely the reinstatement model of alcohol relapse and compulsive alcohol seeking under a chained schedule of reinforcement. We then provide an overview of the neurobiological findings obtained using these animal models, focusing on the role of opioids systems, corticotropin-release hormone and neurokinins, followed by dopaminergic, glutamatergic, and GABAergic neurotransmissions in alcohol seeking behavior.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- alcohol seeking
- animal model
- dopamine
- GABA
- glutamate
- opioid
- receptors
- relapse
- stress
- Biochemistry & Molecular Biology
- Neurosciences & Neurology
- alcohol seeking; animal model; dopamine; GABA; glutamate; opioid receptors; relapse
Publication and Content Type
- ref (subject category)
- for (subject category)
Find in a library
To the university's database