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Preexisting autoant...
Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1.
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Bastard, Paul (author)
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Orlova, Elizaveta (author)
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Sozaeva, Leila (author)
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show more...
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Lévy, Romain (author)
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James, Alyssa (author)
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Schmitt, Monica M (author)
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Ochoa, Sebastian (author)
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Kareva, Maria (author)
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Rodina, Yulia (author)
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Gervais, Adrian (author)
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Le Voyer, Tom (author)
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Rosain, Jérémie (author)
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Philippot, Quentin (author)
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Neehus, Anna-Lena (author)
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Shaw, Elana (author)
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Migaud, Mélanie (author)
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Bizien, Lucy (author)
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- Ekwall, Olov, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Clinical Sciences, Department of Pediatrics,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Berg, Stefan, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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Beccuti, Guglielmo (author)
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Ghizzoni, Lucia (author)
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Thiriez, Gérard (author)
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Pavot, Arthur (author)
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Goujard, Cécile (author)
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Frémond, Marie-Louise (author)
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Carter, Edwin (author)
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Rothenbuhler, Anya (author)
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Linglart, Agnès (author)
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Mignot, Brigite (author)
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Comte, Aurélie (author)
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Cheikh, Nathalie (author)
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Hermine, Olivier (author)
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Breivik, Lars (author)
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Husebye, Eystein S (author)
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Humbert, Sébastien (author)
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Rohrlich, Pierre (author)
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Coaquette, Alain (author)
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Vuoto, Fanny (author)
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Faure, Karine (author)
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Mahlaoui, Nizar (author)
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Kotnik, Primož (author)
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Battelino, Tadej (author)
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Trebušak Podkrajšek, Katarina (author)
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Kisand, Kai (author)
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Ferré, Elise M N (author)
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DiMaggio, Thomas (author)
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Rosen, Lindsey B (author)
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Burbelo, Peter D (author)
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McIntyre, Martin (author)
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Kann, Nelli Y (author)
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Shcherbina, Anna (author)
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Pavlova, Maria (author)
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Kolodkina, Anna (author)
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Holland, Steven M (author)
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Zhang, Shen-Ying (author)
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Crow, Yanick J (author)
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Notarangelo, Luigi D (author)
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Su, Helen C (author)
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Abel, Laurent (author)
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Anderson, Mark S (author)
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Jouanguy, Emmanuelle (author)
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Neven, Bénédicte (author)
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Puel, Anne (author)
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Casanova, Jean-Laurent (author)
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Lionakis, Michail S (author)
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(creator_code:org_t)
- 2021
- 2021
- English.
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In: The Journal of experimental medicine. - 1540-9538. ; 218:7
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Patients with biallelic loss-of-function variants of AIRE suffer from autoimmune polyendocrine syndrome type-1 (APS-1) and produce a broad range of autoantibodies (auto-Abs), including circulating auto-Abs neutralizing most type I interferons (IFNs). These auto-Abs were recently reported to account for at least 10% of cases of life-threatening COVID-19 pneumonia in the general population. We report 22 APS-1 patients from 21 kindreds in seven countries, aged between 8 and 48 yr and infected with SARS-CoV-2 since February 2020. The 21 patients tested had auto-Abs neutralizing IFN-α subtypes and/or IFN-ω; one had anti-IFN-β and another anti-IFN-ε, but none had anti-IFN-κ. Strikingly, 19 patients (86%) were hospitalized for COVID-19 pneumonia, including 15 (68%) admitted to an intensive care unit, 11 (50%) who required mechanical ventilation, and four (18%) who died. Ambulatory disease in three patients (14%) was possibly accounted for by prior or early specific interventions. Preexisting auto-Abs neutralizing type I IFNs in APS-1 patients confer a very high risk of life-threatening COVID-19 pneumonia at any age.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Adolescent
- Adult
- Autoantibodies
- immunology
- COVID-19
- immunology
- Child
- Female
- Humans
- Interferon Type I
- immunology
- Male
- Middle Aged
- Pneumonia
- immunology
- Polyendocrinopathies
- Autoimmune
- immunology
- SARS-CoV-2
- immunology
- Young Adult
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Bastard, Paul
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Orlova, Elizavet ...
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Sozaeva, Leila
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Lévy, Romain
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James, Alyssa
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Schmitt, Monica ...
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show more...
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Ochoa, Sebastian
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Kareva, Maria
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Rodina, Yulia
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Gervais, Adrian
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Le Voyer, Tom
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Rosain, Jérémie
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Philippot, Quent ...
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Neehus, Anna-Len ...
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Shaw, Elana
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Migaud, Mélanie
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Bizien, Lucy
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Ekwall, Olov, 19 ...
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Berg, Stefan, 19 ...
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Beccuti, Gugliel ...
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Ghizzoni, Lucia
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Thiriez, Gérard
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Pavot, Arthur
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Goujard, Cécile
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Frémond, Marie-L ...
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Carter, Edwin
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Rothenbuhler, An ...
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Linglart, Agnès
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Mignot, Brigite
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Comte, Aurélie
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Cheikh, Nathalie
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Hermine, Olivier
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Breivik, Lars
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Husebye, Eystein ...
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Humbert, Sébasti ...
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Rohrlich, Pierre
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Coaquette, Alain
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Vuoto, Fanny
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Faure, Karine
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Mahlaoui, Nizar
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Kotnik, Primož
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Battelino, Tadej
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Trebušak Podkraj ...
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Kisand, Kai
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Ferré, Elise M N
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DiMaggio, Thomas
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Rosen, Lindsey B
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Burbelo, Peter D
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McIntyre, Martin
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Kann, Nelli Y
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Shcherbina, Anna
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Pavlova, Maria
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Kolodkina, Anna
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Holland, Steven ...
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Zhang, Shen-Ying
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Crow, Yanick J
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Notarangelo, Lui ...
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Su, Helen C
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Abel, Laurent
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Anderson, Mark S
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Jouanguy, Emmanu ...
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Neven, Bénédicte
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Puel, Anne
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Casanova, Jean-L ...
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Lionakis, Michai ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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The Journal of e ...
- By the university
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University of Gothenburg