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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06049naa a2201309 4500 | |
| 001 | oai:gup.ub.gu.se/304354 | |
| 003 | SwePub | |
| 008 | 240528s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3043542 URI |
| 024 | 7 | a https://doi.org/10.1084/JEM.202105542 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bastard, Paul4 aut |
| 245 | 1 0 | a Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1. |
| 264 | 1 | c 2021 |
| 520 | a Patients with biallelic loss-of-function variants of AIRE suffer from autoimmune polyendocrine syndrome type-1 (APS-1) and produce a broad range of autoantibodies (auto-Abs), including circulating auto-Abs neutralizing most type I interferons (IFNs). These auto-Abs were recently reported to account for at least 10% of cases of life-threatening COVID-19 pneumonia in the general population. We report 22 APS-1 patients from 21 kindreds in seven countries, aged between 8 and 48 yr and infected with SARS-CoV-2 since February 2020. The 21 patients tested had auto-Abs neutralizing IFN-α subtypes and/or IFN-ω; one had anti-IFN-β and another anti-IFN-ε, but none had anti-IFN-κ. Strikingly, 19 patients (86%) were hospitalized for COVID-19 pneumonia, including 15 (68%) admitted to an intensive care unit, 11 (50%) who required mechanical ventilation, and four (18%) who died. Ambulatory disease in three patients (14%) was possibly accounted for by prior or early specific interventions. Preexisting auto-Abs neutralizing type I IFNs in APS-1 patients confer a very high risk of life-threatening COVID-19 pneumonia at any age. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
| 653 | a Adolescent | |
| 653 | a Adult | |
| 653 | a Autoantibodies | |
| 653 | a immunology | |
| 653 | a COVID-19 | |
| 653 | a immunology | |
| 653 | a Child | |
| 653 | a Female | |
| 653 | a Humans | |
| 653 | a Interferon Type I | |
| 653 | a immunology | |
| 653 | a Male | |
| 653 | a Middle Aged | |
| 653 | a Pneumonia | |
| 653 | a immunology | |
| 653 | a Polyendocrinopathies | |
| 653 | a Autoimmune | |
| 653 | a immunology | |
| 653 | a SARS-CoV-2 | |
| 653 | a immunology | |
| 653 | a Young Adult | |
| 700 | 1 | a Orlova, Elizaveta4 aut |
| 700 | 1 | a Sozaeva, Leila4 aut |
| 700 | 1 | a Lévy, Romain4 aut |
| 700 | 1 | a James, Alyssa4 aut |
| 700 | 1 | a Schmitt, Monica M4 aut |
| 700 | 1 | a Ochoa, Sebastian4 aut |
| 700 | 1 | a Kareva, Maria4 aut |
| 700 | 1 | a Rodina, Yulia4 aut |
| 700 | 1 | a Gervais, Adrian4 aut |
| 700 | 1 | a Le Voyer, Tom4 aut |
| 700 | 1 | a Rosain, Jérémie4 aut |
| 700 | 1 | a Philippot, Quentin4 aut |
| 700 | 1 | a Neehus, Anna-Lena4 aut |
| 700 | 1 | a Shaw, Elana4 aut |
| 700 | 1 | a Migaud, Mélanie4 aut |
| 700 | 1 | a Bizien, Lucy4 aut |
| 700 | 1 | a Ekwall, Olov,d 1968u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Clinical Sciences, Department of Pediatrics,Institute of Medicine, Department of Rheumatology and Inflammation Research4 aut0 (Swepub:gu)xekwol |
| 700 | 1 | a Berg, Stefan,d 1959u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics4 aut0 (Swepub:gu)xbeste |
| 700 | 1 | a Beccuti, Guglielmo4 aut |
| 700 | 1 | a Ghizzoni, Lucia4 aut |
| 700 | 1 | a Thiriez, Gérard4 aut |
| 700 | 1 | a Pavot, Arthur4 aut |
| 700 | 1 | a Goujard, Cécile4 aut |
| 700 | 1 | a Frémond, Marie-Louise4 aut |
| 700 | 1 | a Carter, Edwin4 aut |
| 700 | 1 | a Rothenbuhler, Anya4 aut |
| 700 | 1 | a Linglart, Agnès4 aut |
| 700 | 1 | a Mignot, Brigite4 aut |
| 700 | 1 | a Comte, Aurélie4 aut |
| 700 | 1 | a Cheikh, Nathalie4 aut |
| 700 | 1 | a Hermine, Olivier4 aut |
| 700 | 1 | a Breivik, Lars4 aut |
| 700 | 1 | a Husebye, Eystein S4 aut |
| 700 | 1 | a Humbert, Sébastien4 aut |
| 700 | 1 | a Rohrlich, Pierre4 aut |
| 700 | 1 | a Coaquette, Alain4 aut |
| 700 | 1 | a Vuoto, Fanny4 aut |
| 700 | 1 | a Faure, Karine4 aut |
| 700 | 1 | a Mahlaoui, Nizar4 aut |
| 700 | 1 | a Kotnik, Primož4 aut |
| 700 | 1 | a Battelino, Tadej4 aut |
| 700 | 1 | a Trebušak Podkrajšek, Katarina4 aut |
| 700 | 1 | a Kisand, Kai4 aut |
| 700 | 1 | a Ferré, Elise M N4 aut |
| 700 | 1 | a DiMaggio, Thomas4 aut |
| 700 | 1 | a Rosen, Lindsey B4 aut |
| 700 | 1 | a Burbelo, Peter D4 aut |
| 700 | 1 | a McIntyre, Martin4 aut |
| 700 | 1 | a Kann, Nelli Y4 aut |
| 700 | 1 | a Shcherbina, Anna4 aut |
| 700 | 1 | a Pavlova, Maria4 aut |
| 700 | 1 | a Kolodkina, Anna4 aut |
| 700 | 1 | a Holland, Steven M4 aut |
| 700 | 1 | a Zhang, Shen-Ying4 aut |
| 700 | 1 | a Crow, Yanick J4 aut |
| 700 | 1 | a Notarangelo, Luigi D4 aut |
| 700 | 1 | a Su, Helen C4 aut |
| 700 | 1 | a Abel, Laurent4 aut |
| 700 | 1 | a Anderson, Mark S4 aut |
| 700 | 1 | a Jouanguy, Emmanuelle4 aut |
| 700 | 1 | a Neven, Bénédicte4 aut |
| 700 | 1 | a Puel, Anne4 aut |
| 700 | 1 | a Casanova, Jean-Laurent4 aut |
| 700 | 1 | a Lionakis, Michail S4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för pediatrik4 org |
| 773 | 0 | t The Journal of experimental medicineg 218:7q 218:7x 1540-9538 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/304354 |
| 856 | 4 8 | u https://doi.org/10.1084/JEM.20210554 |
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