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Etiology of Clinica...
Etiology of Clinical Community-Acquired Pneumonia in Swedish Children Aged 1-59 Months with High Pneumococcal Vaccine Coverage-The TREND Study
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- Eklundh, A. (author)
- Karolinska Institutet
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- Rhedin, S. (author)
- Karolinska Institutet
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- Ryd-Rinder, M. (author)
- Karolinska Institutet
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- Andersson, Maria, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Univ Gothenburg, Dept Infect Dis, S-40530 Gothenburg, Sweden.
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- Gantelius, Jesper (author)
- KTH,Nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Prot Sci, Div Nanobiotechnol, SciLifeLab, S-17165 65 Solna, Sweden
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- Gaudenzi, Giulia (author)
- Karolinska Institutet,KTH,Nanobioteknologi,Science for Life Laboratory, SciLifeLab,Karolinska Inst, Dept Global Publ Hlth, S-17177 Stockholm, Sweden; KTH Royal Inst Technol, Dept Prot Sci, Div Nanobiotechnol, SciLifeLab, S-17165 65 Solna, Sweden
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- Lindh, Magnus, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Univ Gothenburg, Dept Infect Dis, S-40530 Gothenburg, Sweden.
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- Peltola, V. (author)
- Univ Turku, Turku Univ Hosp, Dept Paediat & Adolescent Med, FI-20521 Turku, Finland.
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- Waris, M. (author)
- Univ Turku, Inst Biomed, FI-20521 Turku, Finland.;Turku Univ Hosp, Clin Microbiol, FI-20521 Turku, Finland.
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- Naucler, P. (author)
- Karolinska Institutet
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- Mårtensson, Andreas, 1963- (author)
- Uppsala universitet,Internationell barnhälsa och nutrition
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- Alfven, T. (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-04-14
- 2021
- English.
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In: Vaccines. - : MDPI AG. - 2076-393X. ; 9:4
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Abstract
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- (1) Immunization with pneumococcal conjugate vaccines has decreased the burden of community-acquired pneumonia (CAP) in children and likely led to a shift in CAP etiology. (2) The Trial of Respiratory infections in children for ENhanced Diagnostics (TREND) enrolled children 1-59 months with clinical CAP according to the World Health Organization (WHO) criteria at Sachs' Children and Youth Hospital, Stockholm, Sweden. Children with rhonchi and indrawing underwent "bronchodilator challenge". C-reactive protein and nasopharyngeal PCR detecting 20 respiratory pathogens, were collected from all children. Etiology was defined according to an a priori defined algorithm based on microbiological, biochemical, and radiological findings. (3) Of 327 enrolled children, 107 (32%) required hospitalization; 91 (28%) received antibiotic treatment; 77 (24%) had a chest X-ray performed; and 60 (18%) responded to bronchodilator challenge. 243 (74%) episodes were classified as viral, 11 (3%) as mixed viral-bacterial, five (2%) as bacterial, two (0.6%) as atypical bacterial and 66 (20%) as undetermined etiology. After exclusion of children responding to bronchodilator challenge, the proportion of bacterial and mixed viral-bacterial etiology was 1% and 4%, respectively. (4) The novel TREND etiology algorithm classified the majority of clinical CAP episodes as of viral etiology, whereas bacterial etiology was uncommon. Defining CAP in children <5 years is challenging, and the WHO definition of clinical CAP is not suitable for use in children immunized with pneumococcal conjugate vaccines.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- pneumococcal conjugate vaccines
- bacterial pneumonia
- viral pneumonia
- respiratory infection
- etiology
- children
- World Health Organization
- streptococcus-pneumoniae
- infection
- diagnosis
- Immunology
- Research & Experimental Medicine
- pneumococcal conjugate vaccines
Publication and Content Type
- ref (subject category)
- art (subject category)
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Vaccines
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- By the author/editor
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Eklundh, A.
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Rhedin, S.
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Ryd-Rinder, M.
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Andersson, Maria ...
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Gantelius, Jespe ...
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Gaudenzi, Giulia
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Lindh, Magnus, 1 ...
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Peltola, V.
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Waris, M.
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Naucler, P.
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Mårtensson, Andr ...
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Alfven, T.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Infectious Medic ...
- Articles in the publication
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Vaccines
- By the university
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University of Gothenburg
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Royal Institute of Technology
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Uppsala University
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Karolinska Institutet