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- Hong, S. J. (author)
TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- 2021-05-14
- Wiley,2021
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- LIBRIS-ID:oai:gup.ub.gu.se/305426
- https://gup.ub.gu.se/publication/305426URI
- https://doi.org/10.1002/alz.12330DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:147984060URI
Supplementary language notes
- Language:English
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- Introduction Neurofilament light (NfL), chitinase-3-like protein 1 (YKL-40), and neurogranin (Ng) are biomarkers for Alzheimer's disease (AD) to monitor axonal damage, astroglial activation, and synaptic degeneration, respectively. Methods We performed genome-wide association studies (GWAS) using DNA and cerebrospinal fluid (CSF) samples from the EMIF-AD Multimodal Biomarker Discovery study for discovery, and the Alzheimer's Disease Neuroimaging Initiative study for validation analyses. GWAS were performed for all three CSF biomarkers using linear regression models adjusting for relevant covariates. Results We identify novel genome-wide significant associations between DNA variants in TMEM106B and CSF levels of NfL, and between CPOX and YKL-40. We confirm previous work suggesting that YKL-40 levels are associated with DNA variants in CHI3L1. Discussion Our study provides important new insights into the genetic architecture underlying interindividual variation in three AD-related CSF biomarkers. In particular, our data shed light on the sequence of events regarding the initiation and progression of neuropathological processes relevant in AD.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- s disease
- biomarker
- cerebrospinal fluid
- chitinase‐
- 3‐
- like protein 1
- genome‐
- wide association
- study
- neurofilament light
- neurogranin
- genome-wide association
- risk
- proteins
- atlas
- loci
- beta
- Neurosciences & Neurology
Added entries (persons, corporate bodies, meetings, titles ...)
- Dobricic, V. (author)
- Ohlei, O. (author)
- Bos, I. (author)
- Vos, S. J. B. (author)
- Prokopenko, D. (author)
- Tijms, B. M. (author)
- Andreasson, Ulf,1968Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xaulfz (author)
- Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
- Vandenberghe, R. (author)
- Gabel, S. (author)
- Scheltens, P. (author)
- Teunissen, C. E. (author)
- Engelborghs, S. (author)
- Frisoni, G. (author)
- Blin, O. (author)
- Richardson, J. C. (author)
- Bordet, R. (author)
- Lleo, A. (author)
- Alcolea, D. (author)
- Popp, J. (author)
- Clark, C. (author)
- Peyratout, G. (author)
- Martinez-Lage, P. (author)
- Tainta, M. (author)
- Dobson, R. J. B. (author)
- Legido-Quigley, C. (author)
- Sleegers, K. (author)
- Van Broeckhoven, C. (author)
- Tanzi, R. E. (author)
- ten Kate, M. (author)
- Wittig, M. (author)
- Franke, A. (author)
- Lill, C. M. (author)
- Barkhof, F. (author)
- Lovestone, S. (author)
- Streffer, J. (author)
- Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
- Visser, P. J. (author)
- Bertram, L. (author)
- Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)
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- In:Alzheimers & Dementia: Wiley17:10, s. 1628-16401552-52601552-5279
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