Search: onr:"swepub:oai:gup.ub.gu.se/305900" >
Agonistic CD40 ther...
Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma.
-
- van Hooren, Luuk (author)
- Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab
-
- Vaccaro, Alessandra (author)
- Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab
-
- Ramachandran, Mohanraj, 1988- (author)
- Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab,Vaskulärbiologi
-
show more...
-
- Vazaios, Konstantinos (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
-
- Libard, Sylwia (author)
- Uppsala universitet,Klinisk och experimentell patologi,Science for Life Laboratory, SciLifeLab
-
- van de Walle, Tiarne (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk immunologi,Vaskulärbiologi
-
- Georganaki, Maria (author)
- Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab
-
- Huang, Hua, 1986- (author)
- Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab,Klinisk immunologi
-
- Pietilä, Ilkka (author)
- Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab
-
- Lau, Joey, 1979- (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
-
Ulvmar, Maria H (author)
-
- Karlsson, Mikael C I (author)
- Karolinska Institutet
-
- Zetterling, Maria (author)
- Uppsala universitet,Enblad: Neurokirurgi
-
- Mangsbo, Sara M., 1981- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för farmaceutisk biovetenskap
-
- Jakola, Asgeir Store (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
-
- Bontell, Thomas Olsson (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
-
- Smits, Anja (author)
- Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Landtblom: Neurovetenskap,Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg
-
- Essand, Magnus (author)
- Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab
-
- Dimberg, Anna (author)
- Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab
-
show less...
-
(creator_code:org_t)
- 2021-07-05
- 2021
- English.
-
In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
- Related links:
-
https://www.nature.c...
-
show more...
-
https://doi.org/10.1...
-
https://uu.diva-port... (primary) (Raw object)
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Gliomas are brain tumors characterized by an immunosuppressive microenvironment. Immunostimulatory agonistic CD40 antibodies (αCD40) are in clinical development for solid tumors, but are yet to be evaluated for glioma. Here, we demonstrate that systemic delivery of αCD40 in preclinical glioma models induces the formation of tertiary lymphoid structures (TLS) in proximity of meningeal tissue. In treatment-naïve glioma patients, the presence of TLS correlates with increased T cell infiltration. However, systemic delivery of αCD40 induces hypofunctional T cells and impairs the response to immune checkpoint inhibitors in pre-clinical glioma models. This is associated with a systemic induction of suppressive CD11b+ B cells post-αCD40 treatment, which accumulate in the tumor microenvironment. Our work unveils the pleiotropic effects of αCD40 therapy in glioma and reveals that immunotherapies can modulate TLS formation in the brain, opening up for future opportunities to regulate the immune response.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
van Hooren, Luuk
-
Vaccaro, Alessan ...
-
Ramachandran, Mo ...
-
Vazaios, Konstan ...
-
Libard, Sylwia
-
van de Walle, Ti ...
-
show more...
-
Georganaki, Mari ...
-
Huang, Hua, 1986 ...
-
Pietilä, Ilkka
-
Lau, Joey, 1979-
-
Ulvmar, Maria H
-
Karlsson, Mikael ...
-
Zetterling, Mari ...
-
Mangsbo, Sara M. ...
-
Jakola, Asgeir S ...
-
Bontell, Thomas ...
-
Smits, Anja
-
Essand, Magnus
-
Dimberg, Anna
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Nature communica ...
- By the university
-
University of Gothenburg
-
Uppsala University
-
Karolinska Institutet