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Observational cohor...
Observational cohort study in older women with early breast cancer: Use of radiation therapy and impact on health-related quality of life and mortality
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Battisti, N. M. L. (author)
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Hatton, M. Q. (author)
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Reed, M. W. R. (author)
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show more...
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Herbert, E. (author)
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Morgan, J. L. (author)
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Bradburn, M. (author)
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Simcock, R. (author)
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Walters, S. J. (author)
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Collins, K. A. (author)
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Ward, S. E. (author)
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Holmes, G. R. (author)
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Burton, M. (author)
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Lifford, K. J. (author)
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Edwards, A. (author)
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Robinson, T. G. (author)
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Martin, C. (author)
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Chater, T. (author)
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Pemberton, K. J. (author)
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Brennan, A. (author)
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Leung Cheung, K. (author)
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Todd, A. (author)
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- Audisio, Riccardo A (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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Wright, J. (author)
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Green, T. (author)
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Revell, D. (author)
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Gath, J. (author)
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Horgan, K. (author)
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Holcombe, C. (author)
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Winter, M. C. (author)
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Naik, J. (author)
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Parmeshwar, R. (author)
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Gosney, M. A. (author)
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Thompson, A. M. (author)
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Wyld, L. (author)
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Ring, A. (author)
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Bridging the Age Gap, T. M. G. (author)
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
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In: Radiotherapy and Oncology. - : Elsevier BV. - 0167-8140. ; 161, s. 166-176
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Background: Radiotherapy reduces in-breast recurrence risk in early breast cancer (EBC) in older women. This benefit may be small and should be balanced against treatment effect and holistic patient assessment. This study described treatment patterns according to fitness and impact on health-related quality-of-life (HRQoL). Methods: A multicentre, observational study of EBC patients aged ≥ 70 years, undergoing breast-conserving surgery (BCS) or mastectomy, was undertaken. Associations between radiotherapy use, surgery, clinico-pathological parameters, fitness based on geriatric parameters and treatment centre were determined. HRQoL was measured using the European Organisation for the Research and Treatment of Cancer (EORTC) questionnaires. Results: In 2013–2018 2811 women in 56 UK study centres underwent surgery with a median follow-up of 52 months. On multivariable analysis, age and tumour risk predicted radiotherapy use. Among healthier patients (based on geriatric assessments) with high-risk tumours, 534/613 (87.1%) having BCS and 185/341 (54.2%) having mastectomy received radiotherapy. In less fit individuals with low-risk tumours undergoing BCS, 149/207 (72.0%) received radiotherapy. Radiotherapy effects on HRQoL domains, including breast symptoms and fatigue were seen, resolving by 18 months. Conclusion: Radiotherapy use in EBC patients ≥ 70 years is affected by age and recurrence risk, whereas geriatric parameters have limited impact regardless of type of surgery. There was geographical variation in treatment, with some fit older women with high-risk tumours not receiving radiotherapy, and some older, low-risk, EBC patients receiving radiotherapy after BCS despite evidence of limited benefit. The impact on HRQoL is transient. © 2021 Elsevier B.V.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Adjuvant radiotherapy
- Breast cancer
- Comorbidity
- Frailty
- Health-related quality of life
- Older
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Battisti, N. M. ...
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Hatton, M. Q.
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Reed, M. W. R.
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Herbert, E.
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Morgan, J. L.
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Bradburn, M.
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show more...
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Simcock, R.
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Walters, S. J.
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Collins, K. A.
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Ward, S. E.
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Holmes, G. R.
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Burton, M.
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Lifford, K. J.
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Edwards, A.
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Robinson, T. G.
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Martin, C.
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Chater, T.
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Pemberton, K. J.
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Brennan, A.
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Leung Cheung, K.
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Todd, A.
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Audisio, Riccard ...
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Wright, J.
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Green, T.
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Revell, D.
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Gath, J.
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Horgan, K.
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Holcombe, C.
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Winter, M. C.
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Naik, J.
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Parmeshwar, R.
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Gosney, M. A.
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Thompson, A. M.
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Wyld, L.
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Ring, A.
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Bridging the Age ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Radiotherapy and ...
- By the university
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University of Gothenburg