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Cue and Reward Evok...
Cue and Reward Evoked Dopamine Activity Is Necessary for Maintaining Learned Pavlovian Associations
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van Zessen, R. (author)
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Flores-Dourojeanni, J. P. (author)
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Eekel, T. (author)
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van den Reijen, S. (author)
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Lodder, B. (author)
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Omrani, A. (author)
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Smidt, M. P. (author)
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Ramakers, G. M. J. (author)
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van der Plasse, G. (author)
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Stuber, G. D. (author)
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- Adan, Roger A. H. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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(creator_code:org_t)
- 2021-04-22
- 2021
- English.
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In: Journal of Neuroscience. - : Society for Neuroscience. - 0270-6474 .- 1529-2401. ; 41:23, s. 5004-5014
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https://www.jneurosc...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Associating natural rewards with predictive environmental cues is crucial for survival. Dopamine (DA) neurons of the ventral tegmental area (VTA) are thought to play a crucial role in this process by encoding reward prediction errors (RPEs) that have been hypothesized to play a role in associative learning. However, it is unclear whether this signal is still necessary after animals have acquired a cue-reward association. In order to investigate this, we trained mice to learn a Pavlovian cue-reward association. After learning, mice show robust anticipatory and consummatory licking behavior. As expected, calcium activity of VTA DA neurons goes up for cue presentation as well as reward delivery. Optogenetic inhibition during the moment of reward delivery disrupts learned behavior, even in the continued presence of reward. This effect is more pronounced over trials and persists on the next training day. Moreover, outside of the task licking behavior and locomotion are unaffected. Similarly to inhibitions during the reward period, we find that inhibiting cue-induced dopamine (DA) signals robustly decreases learned licking behavior, indicating that cue-related DA signals are a potent driver for learned behavior. Overall, we show that inhibition of either of these DA signals directly impairs the expression of learned associative behavior. Thus, continued DA signaling in a learned state is necessary for consolidating Pavlovian associations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- dopamine
- optogenetics
- Pavlovian conditioning
- reward prediction error
- ventral tegmental area
- nucleus-accumbens dopamine
- ventral tegmental area
- gaba neurons
- acquisition
- activation
- prediction
- behavior
- release
- seeking
- food
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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van Zessen, R.
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Flores-Dourojean ...
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Eekel, T.
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van den Reijen, ...
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Lodder, B.
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Omrani, A.
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show more...
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Smidt, M. P.
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Ramakers, G. M. ...
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van der Plasse, ...
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Stuber, G. D.
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Adan, Roger A. H ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Journal of Neuro ...
- By the university
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University of Gothenburg