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Impaired metabolic ...
Impaired metabolic health over-time and high abdominal fat are prospectively associated with high-sensitivity C-reactive protein in children: The IDEFICS study
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González-Gil, E. M. (author)
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Moreno, L. A. (author)
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Nappo, A. (author)
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Santabárbara, J. (author)
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Wolters, M. (author)
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Russo, P. (author)
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De Henauw, S. (author)
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Veidebaum, T. (author)
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Molnar, D. (author)
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- Hunsberger, Monica, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Fraterman, A. (author)
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Iacoviello, L. (author)
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Tornaritis, M. (author)
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Ahrens, W. (author)
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Bel-Serrat, S. (author)
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(creator_code:org_t)
- 2021-06-25
- 2021
- English.
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In: Pediatric Obesity. - : Wiley. - 2047-6302 .- 2047-6310. ; 16:11
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Abstract
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- Background: Metabolic risk and inflammatory state have an early life onset and are associated with future diseases. Objectives: To assess the association between metabolic syndrome (MetS) and metabolic health with high-sensitive C-reactive protein (hsCRP), cross-sectionally and longitudinally, in children. Methods: 2913 European children (2-10 years) from eight countries from the IDEFICS study were investigated. Data were collected at baseline and 2 years later (follow-up). A MetS z-score was computed with waist circumference (WC), insulin resistance index, blood pressure, high-density lipoprotein cholesterol and triglycerides. Metabolically unhealthy (MU) status was assessed. Multi-level linear and logistic regressions were performed. Results: Among the MetS markers, WC was more consistently associated with hsCRP cross-sectional and prospectively. Baseline MetS score was significantly associated with greater risk of high hsCRP at follow-up and with prevalence and incidence of hsCRP. Those children who became MU overtime were significantly (P <.05) associated with future higher levels of hsCRP, independently of weight status at baseline. Conclusions: Transition over time to a MU state was associated with higher levels of hsCRP at follow-up, independent of weight status at baseline. Screening of metabolic factors and routine measurement of WC are needed to prevent inflammatory status and related chronic diseases in children. © 2021 The Authors. Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- abdominal fat
- children
- Europe
- inflammation
- metabolic health
- metabolic syndrome
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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González-Gil, E. ...
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Moreno, L. A.
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Nappo, A.
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Santabárbara, J.
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Wolters, M.
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Russo, P.
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show more...
-
De Henauw, S.
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Veidebaum, T.
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Molnar, D.
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Hunsberger, Moni ...
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Fraterman, A.
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Iacoviello, L.
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Tornaritis, M.
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Ahrens, W.
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Bel-Serrat, S.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Pediatric Obesit ...
- By the university
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University of Gothenburg