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Electrochemical Mea...
Electrochemical Measurements Reveal Reactive Oxygen Species in Stress Granules**
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- Hu, Keke (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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Relton, E. (author)
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Locker, N. (author)
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- Phan, Nhu TN, 1981 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Ewing, Andrew G, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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(creator_code:org_t)
- 2021-06-09
- 2021
- English.
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In: Angewandte Chemie - International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 60:28, s. 15302-15306
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Abstract
Subject headings
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- Stress granules (SGs) are membrane-less organelles that assemble in the cytoplasm to organize cellular contents and promote rapid adaptation during stress. To understand how SGs contribute to physiological functions, we used electrochemical measurements to detect electroactive species in SGs. With amperometry, we discovered that reactive oxygen species (ROS) are encapsulated inside arsenite-induced SGs, and H2O2 is the main species. The release kinetics of H2O2 from single SGs and the number of H2O2 molecules were quantified. The discovery that SGs contain ROS implicates them as communicators of the cellular stresses rather than a simple endpoint. This may explain how SGs regulate cellular metabolism and stress responses. This may also help better understand their cytoprotective functions in pathological conditions associated with SGs such as neurodegenerative diseases (NDs), cancers and viral infections. © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- amperometry
- microelectrodes
- neurodegeneration
- reactive oxygen species
- stress granules
- Cytology
- Hydrogen peroxide
- Neurodegenerative diseases
- Oxygen
- Cellular metabolism
- Electroactive species
- Electrochemical measurements
- Pathological conditions
- Physiological functions
- Rapid adaptation
- Release kinetics
- Viral infections
- Granulation
Publication and Content Type
- ref (subject category)
- art (subject category)
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