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Dehydro-Tocotrienol...
Dehydro-Tocotrienol-beta Counteracts Oxidative-Stress-Induced Diabetes Complications in db/db Mice
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Dallner, G. (author)
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Bentinger, M. (author)
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- Hussain, Shafaat (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Sinha, I. (author)
- Karolinska Institutet
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Yang, J. N. (author)
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Schwank-Xu, C. (author)
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- Zheng, X. W. (author)
- Karolinska Institutet
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Swiezewska, E. (author)
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- Brismar, K. (author)
- Karolinska Institutet
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Valladolid-Acebes, I. (author)
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Tekle, M. (author)
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(creator_code:org_t)
- 2021-07-02
- 2021
- English.
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In: Antioxidants. - : MDPI AG. - 2076-3921. ; 10:7
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Abstract
Subject headings
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- Hyperglycemia, hyperlipidemia, and adiposity are the main factors that cause inflammation in type 2 diabetes due to excessive ROS production, leading to late complications. To counteract the effects of increased free radical production, we searched for a compound with effective antioxidant properties that can induce coenzyme Q biosynthesis without affecting normal cellular functions. Tocotrienols are members of the vitamin E family, well-known as efficient antioxidants that are more effective than tocopherols. Deh-T3 beta is a modified form of the naturally occurring tocotrienol-beta. The synthesis of this compound involves the sequential modification of geranylgeraniol. In this study, we investigated the effects of this compound in different experimental models of diabetes complications. Deh-T3 beta was found to possess multifaceted capacities. In addition to enhanced wound healing, deh-T3 beta improved kidney and liver functions, reduced liver steatosis, and improved heart recovery after ischemia and insulin sensitivity in adipose tissue in a mice model of type 2 diabetes. Deh-T3 beta exerts these positive effects in several organs of the diabetic mice without reducing the non-fasting blood glucose levels, suggesting that both its antioxidant properties and improvement in mitochondrial function are involved, which are central to reducing diabetes complications.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- coenzyme Q
- antioxidants
- tocotrienol
- diabetes
- oxidative stress
- diabetes complications
- wound healing
- vitamin-e
- coenzyme q(10)
- dysfunction
- biosynthesis
- antioxidant
- metabolism
- cells
- Biochemistry & Molecular Biology
- Pharmacology & Pharmacy
- Food Science
- & Technology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Dallner, G.
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Bentinger, M.
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Hussain, Shafaat
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Sinha, I.
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Yang, J. N.
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Schwank-Xu, C.
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show more...
-
Zheng, X. W.
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Swiezewska, E.
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Brismar, K.
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Valladolid-Acebe ...
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Tekle, M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Antioxidants
- By the university
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University of Gothenburg
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Karolinska Institutet