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Measurement batch d...
Measurement batch differences and between-batch conversion of Alzheimer's disease cerebrospinal fluid biomarker values
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Ma, Y. (author)
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Norton, D. L. (author)
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van Hulle, C. A. (author)
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Chappell, R. J. (author)
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Lazar, K. K. (author)
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Jonaitis, E. M. (author)
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Koscik, R. L. (author)
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Clark, L. R. (author)
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Krause, R. (author)
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- Andreasson, Ulf, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Chin, N. A. (author)
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Bendlin, B. B. (author)
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Asthana, S. (author)
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Okonkwo, O. C. (author)
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Gleason, C. E. (author)
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Johnson, S. C. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Carlsson, C. M. (author)
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(creator_code:org_t)
- 2021-05-25
- 2021
- English.
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In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. - : Wiley. - 2352-8729. ; 13:1
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Abstract
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- Introduction Batch differences in cerebrospinal fluid (CSF) biomarker measurement can introduce bias into analyses for Alzheimer's disease studies. We evaluated and adjusted for batch differences using statistical methods. Methods A total of 792 CSF samples from 528 participants were assayed in three batches for 12 biomarkers and 3 biomarker ratios. Batch differences were assessed using Bland-Altman plot, paired t test, Pitman-Morgan test, and linear regression. Generalized linear models were applied to convert CSF values between batches. Results We found statistically significant batch differences for all biomarkers and ratios, except that neurofilament light was comparable between batches 1 and 2. The conversion models generally had high R-2 except for converting P-tau between batches 1 and 3. Discussion Between-batch conversion allows harmonized CSF values to be used in the same analysis. Such method may be applied to adjust for other sources of variability in measuring CSF or other types of biomarkers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- s disease
- batch difference
- biomarker
- cerebrospinal
- fluid
- conversion
- generalized linear model
- hypothetical model
- csf
- variability
- diagnosis
- standardization
- agreement
- assays
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Ma, Y.
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Norton, D. L.
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van Hulle, C. A.
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Chappell, R. J.
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Lazar, K. K.
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Jonaitis, E. M.
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show more...
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Koscik, R. L.
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Clark, L. R.
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Krause, R.
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Andreasson, Ulf, ...
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Chin, N. A.
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Bendlin, B. B.
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Asthana, S.
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Okonkwo, O. C.
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Gleason, C. E.
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Johnson, S. C.
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Carlsson, C. M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Alzheimer's & De ...
- By the university
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University of Gothenburg