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Impact of a Vancomy...
Impact of a Vancomycin-Induced Shift of the Gut Microbiome in a Gram-Negative Direction on Plasma Factor VIII:C Levels: Results from a Randomized Controlled Trial
- Article/chapterEnglish2022
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2021-08-24
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Georg Thieme Verlag KG,2022
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LIBRIS-ID:oai:gup.ub.gu.se/307398
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https://gup.ub.gu.se/publication/307398URI
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https://doi.org/10.1055/s-0041-1733906DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Rationale Inflammation is present in several conditions associated with risk of venous thromboembolism. The gut microbiome might be a source of systemic inflammation and activation of coagulation, by translocation of lipopolysaccharides from gram-negative bacteria to the systemic circulation. Objective To investigate whether a vancomycin-induced shift of the gut microbiome in a gram-negative direction influences systemic inflammation and plasma factor (F) VIII procoagulant activity (FVIII:C). Methods and Results We performed a randomized controlled trial including 43 healthy volunteers aged 19 to 37 years. Twenty-one were randomized to 7 days of oral vancomycin intake and 22 served as controls. Feces and blood were sampled at baseline, the day after the end of intervention, and 3 weeks after intervention. Gut microbiome composition was assessed by amplicon sequencing. FVIII:C was measured using an activated partial thromboplastin time-based assay, cytokines were measured using multiplex technology, complement activation was measured using the enzyme-linked immunosorbent assay, and high-sensitivity C-reactive protein (CRP) was measured by an immunoturbidimetric assay. Vancomycin intake reduced gut microbiome diversity and increased the abundance of gram-negative bacteria. Change in FVIII:C in the intervention group was +4IU/dL versus -6IU/dL ( p =0.01) in the control group. A similar change was observed for log-transformed CRP (+0.21 mg/dL vs. -0.25mg/dL, p =0.04). The cytokines and complement activation markers remained similar in the two groups. Conclusion The found slight increases in FVIII:C and CRP levels might support the hypothesis that a vancomycin-induced gram-negative shift in the gut microbiome could induce increased systemic inflammation and thereby a procoagulant state.
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Bhoelan, S.
(author)
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Hindberg, K.
(author)
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Davids, M.
(author)
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Nieuwdorp, MaxGothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xnieum
(author)
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Mollnes, T. E.
(author)
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Michelsen, A. E.
(author)
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Ueland, T.
(author)
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Sigrid, K. B.
(author)
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Hansen, J. B.
(author)
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Tichelaar, V.
(author)
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Göteborgs universitetWallenberglaboratoriet
(creator_code:org_t)
Related titles
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In:Thrombosis and Haemostasis: Georg Thieme Verlag KG122:4, s. 540-5510340-62452567-689X
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Grimnes, G.
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Bhoelan, S.
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Hindberg, K.
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Davids, M.
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Nieuwdorp, Max
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Mollnes, T. E.
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show more...
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Michelsen, A. E.
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Ueland, T.
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Sigrid, K. B.
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Hansen, J. B.
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Tichelaar, V.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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Thrombosis and H ...
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University of Gothenburg