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A Plasma Protein Bi...
A Plasma Protein Biomarker Strategy for Detection of Small Intestinal Neuroendocrine Tumors
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- Kjellman, M. (author)
- Karolinska Institutet
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- Knigge, U. (author)
- Department of Endocrinology and Gastrointestinal Surgery, ENETS Neuroendocrine Tumor Centre of Excellence, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, ENETS Neuroendocrine Tumor Ctr Excellence, Dept Endocrinol & Gastrointestinal Surg, Rigshospitalet, Copenhagen, Denmark.
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- Welin, Staffan (author)
- Uppsala universitet,Onkologisk endokrinologi,Univ Uppsala Hosp, ENETS Neuroendocrine Tumor Ctr Excellence, Dept Endocrine Oncol, Uppsala, Sweden.
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- Thiis-Evensen, E. (author)
- Department of Gastroenterology, ENETS Neuroendocrine Tumor Centre of Excellence, Oslo University Hospital, Rikshospitalet, Oslo, Norway,Oslo Univ Hosp, ENETS Neuroendocrine Tumor Ctr Excellence, Dept Gastroenterol, Rikshospitalet, Oslo, Norway.
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- Gronbaek, H. (author)
- Department of Hepatology and Gastroenterology, ENETS Neuroendocrine Tumor Centre of Excellence, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, ENETS Neuroendocrine Tumor Ctr Excellence, Dept Hepatol & Gastroenterol, Aarhus, Denmark.
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- Schalin-Jantti, C. (author)
- Department of Endocrinology, Abdominal Center, University of Helsinki, Helsinki, Finland; Helsinki University Hospital, Helsinki, Finland,Helsinki Univ Hosp, Helsinki, Finland.;Univ Helsinki Helsinki, Abdominal Ctr, Dept Endocrinol, Helsinki, Finland.
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- Sorbye, H. (author)
- Department of Oncology and Department of Clinical Science, Haukeland University Hospital, Bergen, Norway,Haukeland Hosp, Dept Oncol & Dept Clin Sci, Bergen, Norway.
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- Joergensen, M. T. (author)
- Department of Medical Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark,Odense Univ Hosp, Dept Med Gastroenterol & Hepatol, Odense, Denmark.
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- Johanson, Viktor, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Department of Surgery, Institute of Clinical Sciences at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Surg, Gothenburg, Sweden.
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- Metso, S. (author)
- Unit of Endocrinology, Department of Internal Medicine, Tampere University Hospital, Teiskontie Tampere, Tampere, Finland,Tampere Univ Hosp, Dept Internal Med, Unit Endocrinol, Teiskontie Tampere, Tampere, Finland.
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- Waldum, H. (author)
- St. Olavs Hospital, Trondheim, Norway,St Olavs Hosp, Trondheim, Norway.
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- Soreide, J. A. (author)
- Department of Gastrointestinal Surgery, Stavanger University Hospital, Stavanger, Norway,Stavanger Univ Hosp, Dept Gastrointestinal Surg, Stavanger, Norway.
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- Ebeling, T. (author)
- Faculty of Medicine, University of Oulu, Oulu, Finland; Division of Endocrinology, Oulu University Hospital, Oulu, Finland,Univ Oulu, Fac Med, Oulu, Finland.;Oulu Univ Hosp, Div Endocrinol, Oulu, Finland.
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- Lindberg, Fredrik (author)
- Umeå universitet,Kirurgi,Department of Surgery, Norrland University Hospital, Umeå, Sweden,Norrland Univ Hosp, Dept Surg, Umeå, Sweden.
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- Landerholm, Kalle (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Ryhov Cty Hosp, Dept Surg, Dept Clin & Expt Med, Jönköping, Sweden.;Linköping Univ, Jönköping, Sweden.
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- Wallin, Göran, 1952- (author)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ Hosp, Fac Med & Hlth, Örebro, Sweden.
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- Salem, F. (author)
- Skånes University Hospital, Unit for Endocrine and Sarcoma Surgery, Lund, Sweden,Skanes Univ Hosp, Unit Endocrine & Sarcoma Surg, Lund, Sweden.
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- Schneider, M. D. (author)
- IPSEN Innovation SAS, Les Ulis, France,IPSEN Innovat SAS, Les Ulis, France.
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- Belusa, R. (author)
- IPSEN, Kista Science Tower, Kista, Sweden,IPSEN, Kista Sci Tower, Kista, Sweden.
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(creator_code:org_t)
- 2020-07-28
- 2021
- English.
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In: Neuroendocrinology. - : S. Karger AG. - 0028-3835 .- 1423-0194. ; 111:9, s. 840-849
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Abstract
Subject headings
Close
- Background: Small intestinal neuroendocrine tumors (SI-NETs) are difficult to diagnose in the early stage of disease. Current blood biomarkers such as chromogranin A (CgA) and 5-hydroxyindolacetic acid have low sensitivity (SEN) and specificity (SPE). This is a first preplanned interim analysis (Nordic non-interventional, prospective, exploratory, EXPLAIN study [NCT02630654]). Its objective is to investigate if a plasma protein multi-biomarker strategy can improve diagnostic accuracy (ACC) in SI-NETs. Methods: At the time of diagnosis, before any disease-specific treatment was initiated, blood was collected from patients with advanced SI-NETs and 92 putative cancer-related plasma proteins from 135 patients were analyzed and compared with the results of age- and sex-matched controls (n = 143), using multiplex proximity extension assay and machine learning techniques. Results: Using a random forest model including 12 top ranked plasma proteins in patients with SI-NETs, the multi-biomarker strategy showed SEN and SPE of 89 and 91%, respectively, with negative predictive value (NPV) and positive predictive value (PPV) of 90 and 91%, respectively, to identify patients with regional or metastatic disease with an area under the receiver operator characteristic curve (AUROC) of 99%. In 30 patients with normal CgA concentrations, the model provided a diagnostic SPE of 98%, SEN of 56%, and NPV 90%, PPV of 90%, and AUROC 97%, regardless of proton pump inhibitor intake. Conclusion: This interim analysis demonstrates that a multi-biomarker/machine learning strategy improves diagnostic ACC of patients with SI-NET at the time of diagnosis, especially in patients with normal CgA levels. The results indicate that this multi-biomarker strategy can be useful for early detection of SI-NETs at presentation and conceivably detect recurrence after radical primary resection.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Neuroendocrine tumor
- Biomarker
- Diagnosis
- Machine learning
- chromogranin-a
- prognostic-factors
- epidemiology
- diagnosis
- marker
- endocrine
- neoplasms
- disease
- cancer
- Endocrinology & Metabolism
- Neurosciences & Neurology
- Neuroendocrine tumor
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kjellman, M.
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Knigge, U.
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Welin, Staffan
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Thiis-Evensen, E ...
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Gronbaek, H.
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Schalin-Jantti, ...
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show more...
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Sorbye, H.
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Joergensen, M. T ...
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Johanson, Viktor ...
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Metso, S.
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Waldum, H.
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Soreide, J. A.
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Ebeling, T.
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Lindberg, Fredri ...
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Landerholm, Kall ...
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Wallin, Göran, 1 ...
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Salem, F.
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Schneider, M. D.
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Belusa, R.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Neuroendocrinolo ...
- By the university
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University of Gothenburg
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Örebro University
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Umeå University
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Linköping University
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Uppsala University
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Karolinska Institutet