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Diagnostic and prog...
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Chatterjee, Pratishtha
(author)
Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's disease.
- Article/chapterEnglish2022
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Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/307514
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https://gup.ub.gu.se/publication/307514URI
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https://doi.org/10.1002/alz.12447DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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This study involved a parallel comparison of the diagnostic and longitudinal monitoring potential of plasma glial fibrillary acidic protein (GFAP), total tau (t-tau), phosphorylated tau (p-tau181 and p-tau231), and neurofilament light (NFL) in preclinical Alzheimer's disease (AD).Plasma proteins were measured using Simoa assays in cognitively unimpaired older adults (CU), with either absence (Aβ-) or presence (Aβ+) of brain amyloidosis.Plasma GFAP, t-tau, p-tau181, and p-tau231 concentrations were higher in Aβ+ CU compared with Aβ- CU cross-sectionally. GFAP had the highest effect size and area under the curve (AUC) in differentiating between Aβ+ and Aβ- CU; however, no statistically significant differences were observed between the AUCs of GFAP, p-tau181, and p-tau231, but all were significantly higher than the AUC of NFL, and the AUC of GFAP was higher than the AUC of t-tau. The combination of a base model (BM), comprising the AD risk factors, age, sex, and apolipoprotein E gene (APOE) ε4 status with GFAP was observed to have a higher AUC (>90%) compared with the combination of BM with any of the other proteins investigated in the current study. Longitudinal analyses showed increased GFAP and p-tau181 in Aβ+ CU and increased NFL in Aβ- CU, over a 12-month duration. GFAP, p-tau181, p-tau231, and NFL showed significant correlations with cognition, whereas no significant correlations were observed with hippocampal volume.These findings highlight the diagnostic and longitudinal monitoring potential of GFAP and p-tau for preclinical AD.
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Pedrini, Steve
(author)
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Ashton, Nicholas J.Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xashtn
(author)
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Tegg, Michelle
(author)
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Goozee, Kathryn
(author)
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Singh, Abhay K
(author)
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Karikari, ThomasGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xkarit
(author)
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Simrén, Joel,1996Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xsimrj
(author)
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Vanmechelen, Eugeen
(author)
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Armstrong, Nicola J
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Hone, Eugene
(author)
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Asih, Prita R
(author)
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Taddei, Kevin
(author)
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Doré, Vincent
(author)
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Villemagne, Victor L
(author)
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Sohrabi, Hamid R
(author)
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
(author)
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Masters, Colin L
(author)
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(author)
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Martins, Ralph N
(author)
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
Related titles
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In:Alzheimer's & dementia : the journal of the Alzheimer's Association: Wiley18:6, s. 1141-11541552-5279
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In:Alzheimer's & Dementia: Wiley18:6, s. 1141-11541552-5260
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Chatterjee, Prat ...
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Pedrini, Steve
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Ashton, Nicholas ...
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Tegg, Michelle
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Goozee, Kathryn
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Singh, Abhay K
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Karikari, Thomas
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Hone, Eugene
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Asih, Prita R
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Taddei, Kevin
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Doré, Vincent
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Villemagne, Vict ...
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Sohrabi, Hamid R
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Zetterberg, Henr ...
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Masters, Colin L
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Blennow, Kaj, 19 ...
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Martins, Ralph N
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