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- Abe, C.Karolinska Institutet (author)
Genetic risk for bipolar disorder and schizophrenia predicts structure and function of the ventromedial prefrontal cortex
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- 2021-07-01
- CMA Joule Inc.2021
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- LIBRIS-ID:oai:gup.ub.gu.se/307629
- https://gup.ub.gu.se/publication/307629URI
- https://doi.org/10.1503/jpn.200165DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:147291276URI
Supplementary language notes
- Language:English
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- Background: Bipolar disorder is highly heritable and polygenic. The polygenic risk for bipolar disorder overlaps with that of schizophrenia, and polygenic scores are normally distributed in the population. Bipolar disorder has been associated with structural brain abnormalities, but it is unknown how these are linked to genetic risk factors for psychotic disorders. Methods: We tested whether polygenic risk scores for bipolar disorder and schizophrenia predict structural brain alterations in 98 patients with bipolar disorder and 81 healthy controls. We derived brain cortical thickness, surface area and volume from structural MRI scans. In post-hoc analyses, we correlated polygenic risk with functional hub strength, derived from resting-state functional MRI and brain connectomics. Results: Higher polygenic risk scores for both bipolar disorder and schizophrenia were associated with a thinner ventromedial prefrontal cortex (vmPFC). We found these associations in the combined group, and separately in patients and drug-naive controls. Polygenic risk for bipolar disorder was correlated with the functional hub strength of the vmPFC within the default mode network. Limitations: Polygenic risk is a cumulative measure of genomic burden. Detailed genetic mechanisms underlying brain alterations and their cognitive consequences still need to be determined. Conclusion: Our multimodal neuroimaging study linked genomic burden and brain endophenotype by demonstrating an association between polygenic risk scores for bipolar disorder and schizophrenia and the structure and function of the vmPFC. Our findings suggest that genetic factors might confer risk for psychotic disorders by influencing the integrity of the vmPFC, a brain region involved in self-referential processes and emotional regulation. Our study may also provide an imaging-genetics vulnerability marker that can be used to help identify individuals at risk for developing bipolar disorder.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
- human cerebral-cortex
- surface-based analysis
- cortical thickness
- association
- network
- self
- mri
- segmentation
- variants
- area
- Neurosciences & Neurology
- Psychiatry
Added entries (persons, corporate bodies, meetings, titles ...)
- Petrovic, P.Karolinska Institutet (author)
- Ossler, W. (author)
- Thompson, William Hedley,1987Karolinska Institutet(Swepub:gu)xthowi (author)
- Liberg, B. (author)
- Song, J.Karolinska Institutet (author)
- Bergen, S. E.Karolinska Institutet (author)
- Sellgren, C. M.Karolinska Institutet (author)
- Fransson, P. (author)
- Ingvar, M.Karolinska Institutet (author)
- Landén, Mikael,1966Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xlandt (author)
- Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)
Related titles
- In:Journal of Psychiatry & Neuroscience: CMA Joule Inc.46:41180-48821488-2434
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