Search: onr:"swepub:oai:gup.ub.gu.se/307833" >
Following spatial A...
-
Michno, Wojciech,1992Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
(author)
Following spatial Aβ aggregation dynamics in evolving Alzheimer's disease pathology by imaging stable isotope labeling kinetics
- Article/chapterEnglish2021
Publisher, publication year, extent ...
-
American Association for the Advancement of Science (AAAS),2021
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/307833
-
https://gup.ub.gu.se/publication/307833URI
-
https://doi.org/10.1126/sciadv.abg4855DOI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
β-Amyloid (Aβ) plaque formation is the major pathological hallmark of Alzheimer's disease (AD) and constitutes a potentially critical, early inducer driving AD pathogenesis as it precedes other pathological events and cognitive symptoms by decades. It is therefore critical to understand how Aβ pathology is initiated and where and when distinct Aβ species aggregate. Here, we used metabolic isotope labeling in APPNL-G-F knock-in mice together with mass spectrometry imaging to monitor the earliest seeds of Aβ deposition through ongoing plaque development. This allowed visualizing Aβ aggregation dynamics within single plaques across different brain regions. We show that formation of structurally distinct plaques is associated with differential Aβ peptide deposition. Specifically, Aβ1-42 is forming an initial core structure followed by radial outgrowth and late secretion and deposition of Aβ1-38. These data describe a detailed picture of the earliest events of precipitating amyloid pathology at scales not previously possible. Copyright © 2021 The Authors, some rights reserved.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Stringer, K. M.
(author)
-
Enzlein, T.
(author)
-
Passarelli, M. K.
(author)
-
Escrig, S.
(author)
-
Vitanova, K.
(author)
-
Wood, J.
(author)
-
Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(author)
-
Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
(author)
-
Meibom, A.
(author)
-
Hopf, C.
(author)
-
Edwards, F. A.
(author)
-
Hanrieder, Jörg,1980Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xhanrj
(author)
-
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
Related titles
-
In:Science Advances: American Association for the Advancement of Science (AAAS)7:252375-2548
Internet link
Find in a library
To the university's database
- By the author/editor
-
Michno, Wojciech ...
-
Stringer, K. M.
-
Enzlein, T.
-
Passarelli, M. K ...
-
Escrig, S.
-
Vitanova, K.
-
show more...
-
Wood, J.
-
Blennow, Kaj, 19 ...
-
Zetterberg, Henr ...
-
Meibom, A.
-
Hopf, C.
-
Edwards, F. A.
-
Hanrieder, Jörg, ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Science Advances
- By the university
-
University of Gothenburg