Search: onr:"swepub:oai:gup.ub.gu.se/307998" > The genomics of hea...
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001 | oai:gup.ub.gu.se/307998 | |
003 | SwePub | |
008 | 240528s2021 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-463090 | |
009 | oai:DiVA.org:du-38289 | |
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009 | oai:prod.swepub.kib.ki.se:147534502 | |
024 | 7 | a https://gup.ub.gu.se/publication/3079982 URI |
024 | 7 | a https://doi.org/10.1002/ehf2.135172 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4630902 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:du-382892 URI |
024 | 7 | a https://lup.lub.lu.se/record/469618eb-613c-479c-b61a-126e0fbf79942 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1475345022 URI |
040 | a (SwePub)gud (SwePub)uud (SwePub)dud (SwePub)lud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Lumbers, R. T.u Institute of Health Informatics University College London Gower St London WC1E 7HB UK;Health Data Research UK London University College London London UK;BHF Research Accelerator University College London London UK4 aut |
245 | 1 0 | a The genomics of heart failure: design and rationale of the HERMES consortium |
264 | c 2021-09-03 | |
264 | 1 | b Wiley,c 2021 |
520 | a Aims The HERMES (HEart failure Molecular Epidemiology for Therapeutic targets) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of >1.10 for common variants (allele frequency > 0.05) and >1.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 x 10(-8) under an additive genetic model. Conclusions HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a Heart failure | |
653 | a Cardiomyopathy | |
653 | a Genetics | |
653 | a Biomarkers | |
653 | a Association studies | |
653 | a wide association | |
653 | a african ancestry | |
653 | a aging research | |
653 | a epidemiology | |
653 | a metaanalysis | |
653 | a classification | |
653 | a replication | |
653 | a cohorts | |
653 | a adults | |
653 | a risk | |
653 | a Cardiovascular System & Cardiology | |
653 | a Heart failure | |
700 | 1 | a Shah, S.u Institute for Molecular Bioscience The University of Queensland Brisbane Queensland Australia;Institute of Cardiovascular Science University College London London UK,Division of Molecular and Clinical Medicine University of Dundee, Ninewells Hospital and Medical School Dundee UK4 aut |
700 | 1 | a Lin, H. H.u Section of Computational Biomedicine, Department of Medicine Boston University School of Medicine Boston MA USA;National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study Framingham MA USA,Institute of Health Informatics University College London Gower St London WC1E 7HB UK;Health Data Research UK London University College London London UK;The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London London UK,Division of Cardiology, Department of Medicine Emory University Medical Center Atlanta GA USA4 aut |
700 | 1 | a Czuba, Tomaszu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)to6882cz |
700 | 1 | a Henry, A.u Institute of Health Informatics University College London Gower St London WC1E 7HB UK;Institute of Cardiovascular Science University College London London UK4 aut |
700 | 1 | a Swerdlow, D. I.u Institute of Cardiovascular Science University College London London UK;Department of Medicine Imperial College London London UK4 aut |
700 | 1 | a Malarstig, A.u Karolinska Institute,Pfizer Inc. US4 aut |
700 | 1 | a Andersson, C.u National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study Framingham MA USA;Department of Cardiology Herlev Gentofte Hospital Herlev Denmark4 aut |
700 | 1 | a Verweij, N.u Department of Cardiology University of Groningen, University Medical Center Groningen Groningen The Netherlands4 aut |
700 | 1 | a Holmes, M. V.u Medical Research Council Population Health Research Unit at the University of Oxford Oxford UK;Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, Big Data Institute University of Oxford Oxford UK;National Institute for Health Research Oxford Biomedical Research Centre Oxford University Hospital Oxford UK,Oxford University Hospitals NHS Foundation Trust4 aut |
700 | 1 | a Ärnlöv, Johan,d 1970-u Karolinska Institute,Dalarna University College,Högskolan Dalarna,Medicinsk vetenskap,Karolinska Institutet, Stockholm4 aut0 (Swepub:du)jan |
700 | 1 | a Svensson, P.u Karolinska Institutet,Karolinska Institute,Stockholm South General Hospital4 aut |
700 | 1 | a Hemingway, H.u Regeneron Genetics Center Tarrytown NY USA,Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Sallah, N.u Institute of Health Informatics University College London Gower St London WC1E 7HB UK;Health Data Research UK London University College London London UK;UCL Genetics Institute University College London London UK4 aut |
700 | 1 | a Almgren, Peteru Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)endo-pal |
700 | 1 | a Aragam, K. G.u Program in Medical and Population Genetics The Broad Institute of MIT and Harvard Cambridge MA USA;Center for Genomic Medicine Massachusetts General Hospital Boston MA USA;Cardiovascular Research Center Massachusetts General Hospital Boston MA USA4 aut |
700 | 1 | a Asselin, G.u Montreal Heart Institute Montreal Quebec Canada4 aut |
700 | 1 | a Backman, J. D.u Regeneron Genetics Center Tarrytown NY USA,Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Lind, Larsu Uppsala universitet,Klinisk epidemiologi,Washington University School of Medicine4 aut0 (Swepub:uu)larslind |
700 | 1 | a Bloom, H. L.4 aut |
700 | 1 | a Boersma, E.u Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands4 aut |
700 | 1 | a Brandimarto, J.u Penn Cardiovascular Institute, Perelman School of Medicine University of Pennsylvania Philadelphia PA USA4 aut |
700 | 1 | a Brown, M. R.u Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health The University of Texas Health Science Center at Houston Houston TX USA4 aut |
700 | 1 | a Brunner-La Rocca, H. P.u Maastricht University Medical Center Maastricht The Netherlands,Yukioka Hospital4 aut |
700 | 1 | a Carey, D. J.u Department of Molecular and Functional Genomics Geisinger Danville PA USA,Geisinger Health System4 aut |
700 | 1 | a Chaffin, M. D.u Cardiovascular Disease Initiative The Broad Institute of MIT and Harvard Cambridge MA USA,Department of Internal Medicine B University Medicine Greifswald Greifswald Germany;DZHK (German Center for Cardiovascular Research), partner site Greifswald Greifswald Germany,University Hospital Greifswald4 aut |
700 | 1 | a Chasman, D. I.u Division of Preventive Medicine Brigham and Women's Hospital Boston MA USA;Harvard Medical School Boston MA USA4 aut |
700 | 1 | a Chazara, O.u Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D AstraZeneca Cambridge UK4 aut |
700 | 1 | a Chen, X.u Karolinska Institute4 aut |
700 | 1 | a Chen, X.4 aut |
700 | 1 | a Chung, J. H.4 aut |
700 | 1 | a Chutkow, W.u Novartis Institutes for Biomedical Research Cambridge MA USA,Novartis Institutes for BioMedical Research, Inc.4 aut |
700 | 1 | a Cleland, J. G. F.u Robertson Centre for Biostatistics & Glasgow Clinical Trials Unit, Institute of Health and Wellbeing University of Glasgow, Glasgow Royal Infirmary Glasgow UK;National Heart and Lung Institute Imperial College London UK,Institute of Health Informatics University College London Gower St London WC1E 7HB UK;Health Data Research UK London University College London London UK,Translational and Clinical Research Servier Cardiovascular Center for Therapeutic Innovation Suresnes France4 aut |
700 | 1 | a Cook, J. P.u Department of Biostatistics University of Liverpool Liverpool UK4 aut |
700 | 1 | a de Denus, S.u Montreal Heart Institute Montreal Quebec Canada;Faculty of Pharmacy Université de Montréal Montreal Quebec Canada4 aut |
700 | 1 | a Dehghan, A.u Department of Epidemiology and Biostatistics Imperial College London, St Mary's Campus London UK;MRC‐PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics Imperial College London, St Mary's Campus London UK4 aut |
700 | 1 | a Engström, Gunnaru Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)smi-gen |
700 | 1 | a Denaxas, S.u Institute of Health Informatics University College London Gower St London WC1E 7HB UK;Health Data Research UK London University College London London UK;The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London London UK;The Alan Turing Institute, British Library London UK4 aut |
700 | 1 | a Doney, A. S.4 aut |
700 | 1 | a Dorr, M.4 aut |
700 | 1 | a Dudley, S. C.u Cardiovascular Division, Department of Medicine University of Minnesota Minneapolis MN USA4 aut |
700 | 1 | a Engstrom, G.4 aut |
700 | 1 | a Esko, T.u Program in Medical and Population Genetics The Broad Institute of MIT and Harvard Cambridge MA USA;Estonian Genome Center, Institute of Genomics University of Tartu Tartu Estonia4 aut |
700 | 1 | a Fatemifar, G.4 aut |
700 | 1 | a Felix, S. B.u Department of Internal Medicine B University Medicine Greifswald Greifswald Germany;DZHK (German Center for Cardiovascular Research), partner site Greifswald Greifswald Germany,University Hospital Greifswald4 aut |
700 | 1 | a Finan, C.u Institute of Cardiovascular Science University College London London UK4 aut |
700 | 1 | a Ford, I.u Robertson Centre for Biostatistics & Glasgow Clinical Trials Unit, Institute of Health and Wellbeing University of Glasgow, Glasgow Royal Infirmary Glasgow UK4 aut |
700 | 1 | a Fougerousse, F.4 aut |
700 | 1 | a Fouodjio, R.u Montreal Heart Institute Montreal Quebec Canada4 aut |
700 | 1 | a Ghanbari, M.u Department of Epidemiology Erasmus University Medical Center Rotterdam The Netherlands4 aut |
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700 | 1 | a Giedraitis, Vilmantasu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)vigie517 |
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700 | 1 | a Smith, J. Gustav,d 1982u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory4 aut0 (Swepub:gu)xsmigu |
710 | 2 | a Institute of Health Informatics University College London Gower St London WC1E 7HB UK;Health Data Research UK London University College London London UK;BHF Research Accelerator University College London London UKb Institute for Molecular Bioscience The University of Queensland Brisbane Queensland Australia;Institute of Cardiovascular Science University College London London UK4 org |
710 | 2 | a Regeneron Genetics Center |
773 | 0 | t Esc Heart Failured : Wileyg 8:6, s. 5531-5541q 8:6<5531-5541x 2055-5822 |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ehf2.13517 |
856 | 4 | u https://doi.org/10.1002/ehf2.13517y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1625037/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://du.diva-portal.org/smash/get/diva2:1597601/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://dx.doi.org/10.1002/ehf2.13517x freey FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/307998 |
856 | 4 8 | u https://doi.org/10.1002/ehf2.13517 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-463090 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:du-38289 |
856 | 4 8 | u https://lup.lub.lu.se/record/469618eb-613c-479c-b61a-126e0fbf7994 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:147534502 |
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