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ILB(R) Attenuates C...
ILB(R) Attenuates Clinical Symptoms and Serum Biomarkers of Oxidative/Nitrosative Stress and Mitochondrial Dysfunction in Patients with Amyotrophic Lateral Sclerosis
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Lazzarino, G. (author)
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Mangione, R. (author)
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Belli, A. (author)
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Di Pietro, V. (author)
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Nagy, Z. (author)
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Barnes, N. M. (author)
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Bruce, L. (author)
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- Ropero, Bernardo M. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Persson, Lennart I. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Manca, B. (author)
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Saab, M. W. (author)
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Amorini, A. M. (author)
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Tavazzi, B. (author)
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Lazzarino, G. (author)
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Logan, A. (author)
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(creator_code:org_t)
- 2021-08-14
- 2021
- English.
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In: Journal of Personalized Medicine. - : MDPI AG. - 2075-4426. ; 11:8
- Related links:
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https://www.mdpi.com...
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Subject headings
Close
- Oxidative/nitrosative stress and mitochondrial dysfunction is a hallmark of amyotrophic lateral sclerosis (ALS), an invariably fatal progressive neurodegenerative disease. Here, as an exploratory arm of a phase II clinical trial (EudraCT Number 2017-005065-47), we used high performance liquid chromatography(HPLC) to investigate changes in the metabolic profiles of serum from ALS patients treated weekly for 4 weeks with a repeated sub-cutaneous dose of 1 mg/kg of a proprietary low molecular weight dextran sulphate, called ILB(R). A significant normalization of the serum levels of several key metabolites was observed over the treatment period, including N-acetylaspartate (NAA), oxypurines, biomarkers of oxidative/nitrosative stress and antioxidants. An improved serum metabolic profile was accompanied by significant amelioration of the patients' clinical conditions, indicating a response to ILB(R) treatment that appears to be mediated by improvement of tissue bioenergetics, decrease of oxidative/nitrosative stress and attenuation of (neuro)inflammatory processes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- amyotrophic lateral sclerosis
- low molecular weight-dextran sulphate
- serum biomarkers
- energy metabolism
- mitochondrial dysfunction
- N-acetylaspartate
- amino acids
- oxidative
- nitrosative stress
- antioxidants
- HPLC
- metabolic brain vulnerability
- energy-metabolism
- temporal window
- lipid-peroxidation
- oxidative stress
- inborn-errors
- amino-acid
- in-vivo
- impairment
- spectroscopy
- Health Care Sciences & Services
- General & Internal Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Lazzarino, G.
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Mangione, R.
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Belli, A.
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Di Pietro, V.
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Nagy, Z.
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Barnes, N. M.
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show more...
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Bruce, L.
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Ropero, Bernardo ...
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Persson, Lennart ...
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Manca, B.
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Saab, M. W.
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Amorini, A. M.
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Tavazzi, B.
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Logan, A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Journal of Perso ...
- By the university
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University of Gothenburg