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Central sensitisati...
Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine
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- Nijs, Jo (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering,Centrum för personcentrerad vård vid Göteborgs universitet (GPCC),Institute of Neuroscience and Physiology, Department of Health and Rehabilitation,University of Gothenburg Centre for person-centred care (GPCC)
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George, S. Z. (author)
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Clauw, D. J. (author)
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Fernandez-de-las-Penas, C. (author)
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Kosek, E. (author)
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Ickmans, K. (author)
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Fernandez-Carnero, J. (author)
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Polli, A. (author)
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Kapreli, E. (author)
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Huysmans, E. (author)
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Cuesta-Vargas, A. I. (author)
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Mani, R. (author)
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- Lundberg, Mari, 1969 (author)
- Gothenburg University,Göteborgs universitet,Centrum för personcentrerad vård vid Göteborgs universitet (GPCC),Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering,University of Gothenburg Centre for person-centred care (GPCC),Institute of Neuroscience and Physiology, Department of Health and Rehabilitation
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Leysen, L. (author)
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Rice, D. (author)
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Sterling, M. (author)
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Curatolo, M. (author)
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
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In: Lancet Rheumatology. - : Elsevier BV. - 2665-9913. ; 3:5
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http://www.thelancet...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Chronic pain is a leading cause of disability globally and associated with enormous health-care costs. The discrepancy between the extent of tissue damage and the magnitude of pain, disability, and associated symptoms represents a diagnostic challenge for rheumatology specialists. Central sensitisation, defined as an amplification of neural signalling within the CNS that elicits pain hypersensitivity, has been investigated as a reason for this discrepancy. Features of central sensitisation have been documented in various pain conditions common in rheumatology practice, including fibromyalgia, osteoarthritis, rheumatoid arthritis, Ehlers-Danlos syndrome, upper extremity tendinopathies, headache, and spinal pain. Within individual pain conditions, there is substantial variation among patients in terms of presence and magnitude of central sensitisation, stressing the importance of individual assessment. Central sensitisation predicts poor treatment outcomes in multiple patient populations. The available evidence supports various pharmacological and non-pharmacological strategies to reduce central sensitisation and to improve patient outcomes in several conditions commonly seen in rheumatology practice. These data open up new treatment perspectives, with the possibility for precision pain medicine treatment according to pain phenotyping as a logical next step. With this view, studies suggest the possibility of matching non-pharmacological approaches, or medications, or both to the central sensitisation pain
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- low-back-pain
- total knee arthroplasty
- nervous-system sensitization
- nontraumatic neck pain
- fibromyalgia syndrome
- rheumatoid-arthritis
- postoperative pain
- danlos-syndrome
- shoulder pain
- double-blind
- Rheumatology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Nijs, Jo
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George, S. Z.
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Clauw, D. J.
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Fernandez-de-las ...
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Kosek, E.
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Ickmans, K.
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show more...
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Fernandez-Carner ...
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Polli, A.
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Kapreli, E.
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Huysmans, E.
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Cuesta-Vargas, A ...
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Mani, R.
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Lundberg, Mari, ...
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Leysen, L.
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Rice, D.
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Sterling, M.
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Curatolo, M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Lancet Rheumatol ...
- By the university
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University of Gothenburg