Search: onr:"swepub:oai:gup.ub.gu.se/308126" >
Unbiased identifica...
Unbiased identification of novel transcription factors in striatal compartmentation and striosome maturation.
-
Cirnaru, Maria-Daniela (author)
-
Song, Sicheng (author)
-
Tshilenge, Kizito-Tshitoko (author)
-
show more...
-
Corwin, Chuhyon (author)
-
Mleczko, Justyna (author)
-
Galicia Aguirre, Carlos (author)
-
Benlhabib, Houda (author)
-
Bendl, Jaroslav (author)
-
Apontes, Pasha (author)
-
Fullard, John (author)
-
Creus-Muncunill, Jordi (author)
-
- Reyahi, Azadeh (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
-
- Nik, Ali Moussavi (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
-
- Carlsson, Peter, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
-
Roussos, Panos (author)
-
Mooney, Sean D (author)
-
Ellerby, Lisa M (author)
-
Ehrlich, Michelle E (author)
-
show less...
-
(creator_code:org_t)
- 2021
- 2021
- English.
-
In: eLife. - 2050-084X. ; 10
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.7...
-
show less...
Abstract
Subject headings
Close
- Many diseases are linked to dysregulation of the striatum. Striatal function depends on neuronal compartmentation into striosomes and matrix. Striatal projection neurons are GABAergic medium spiny neurons (MSNs), subtyped by selective expression of receptors, neuropeptides, and other gene families. Neurogenesis of the striosome and matrix occurs in separate waves, but the factors regulating compartmentation and neuronal differentiation are largely unidentified. We performed RNA- and ATAC-seq on sorted striosome and matrix cells at postnatal day 3, using the Nr4a1-EGFP striosome reporter mouse. Focusing on the striosome, we validated the localization and/or role of Irx1, Foxf2, Olig2, and Stat1/2 in the developing striosome and the in vivo enhancer function of a striosome-specific open chromatin region 4.4 Kb downstream of Olig2. These data provide novel tools to dissect and manipulate the networks regulating MSN compartmentation and differentiation, including in human iPSC-derived striatal neurons for disease modeling and drug discovery.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
eLife
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Cirnaru, Maria-D ...
-
Song, Sicheng
-
Tshilenge, Kizit ...
-
Corwin, Chuhyon
-
Mleczko, Justyna
-
Galicia Aguirre, ...
-
show more...
-
Benlhabib, Houda
-
Bendl, Jaroslav
-
Apontes, Pasha
-
Fullard, John
-
Creus-Muncunill, ...
-
Reyahi, Azadeh
-
Nik, Ali Moussav ...
-
Carlsson, Peter, ...
-
Roussos, Panos
-
Mooney, Sean D
-
Ellerby, Lisa M
-
Ehrlich, Michell ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
- Articles in the publication
-
eLife
- By the university
-
University of Gothenburg