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Characteristics and...
Characteristics and outcomes of 627 044 COVID-19 patients living with and without obesity in the United States, Spain, and the United Kingdom
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-07-15
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Springer Science and Business Media LLC,2021
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LIBRIS-ID:oai:gup.ub.gu.se/308354
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https://gup.ub.gu.se/publication/308354URI
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https://doi.org/10.1038/s41366-021-00893-4DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Background A detailed characterization of patients with COVID-19 living with obesity has not yet been undertaken. We aimed to describe and compare the demographics, medical conditions, and outcomes of COVID-19 patients living with obesity (PLWO) to those of patients living without obesity. Methods We conducted a cohort study based on outpatient/inpatient care and claims data from January to June 2020 from Spain, the UK, and the US. We used six databases standardized to the OMOP common data model. We defined two non-mutually exclusive cohorts of patients diagnosed and/or hospitalized with COVID-19; patients were followed from index date to 30 days or death. We report the frequency of demographics, prior medical conditions, and 30-days outcomes (hospitalization, events, and death) by obesity status. Results We included 627 044 (Spain: 122 058, UK: 2336, and US: 502 650) diagnosed and 160 013 (Spain: 18 197, US: 141 816) hospitalized patients with COVID-19. The prevalence of obesity was higher among patients hospitalized (39.9%, 95%CI: 39.8-40.0) than among those diagnosed with COVID-19 (33.1%; 95%CI: 33.0-33.2). In both cohorts, PLWO were more often female. Hospitalized PLWO were younger than patients without obesity. Overall, COVID-19 PLWO were more likely to have prior medical conditions, present with cardiovascular and respiratory events during hospitalization, or require intensive services compared to COVID-19 patients without obesity. Conclusion We show that PLWO differ from patients without obesity in a wide range of medical conditions and present with more severe forms of COVID-19, with higher hospitalization rates and intensive services requirements. These findings can help guiding preventive strategies of COVID-19 infection and complications and generating hypotheses for causal inference studies.
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Roel, E.
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Pistillo, A.
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Sena, A. G.
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Prats-Uribe, A.
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Ahmed, W. U.
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Alghoul, H.
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Alshammari, T. M.
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Alser, O.
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Areia, C.
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Burn, E.
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Casajust, P.
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Dawoud, D.
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DuVall, S. L.
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Falconer, T.
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Fernandez-Bertolin, S.
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Golozar, A.
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Gong, M. C.
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Lai, L. Y. H.
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Lane, J. C. E.
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Lynch, K. E.
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Matheny, M. E.
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Mehta, P. P.
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Morales, D. R.
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Natarjan, K.
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Nyberg, Fredrik,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xnybef
(author)
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Posada, J. D.
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Reich, C. G.
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Rijnbeek, P. R.
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Schilling, L. M.
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Shah, K.
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Shah, N. H.
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Subbian, V.
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Zhang, L.
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Zhu, H.
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Ryan, P.
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Prieto-Alhambra, D.
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Kostka, K.
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Duarte-Salles, T.
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Göteborgs universitetInstitutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
(creator_code:org_t)
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In:International Journal of Obesity: Springer Science and Business Media LLC45:11, s. 2347-23570307-05651476-5497
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Recalde, M.
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Roel, E.
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Pistillo, A.
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Sena, A. G.
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Prats-Uribe, A.
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Ahmed, W. U.
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Alghoul, H.
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Alshammari, T. M ...
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Alser, O.
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Areia, C.
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Burn, E.
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Casajust, P.
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Dawoud, D.
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DuVall, S. L.
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Falconer, T.
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Fernandez-Bertol ...
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Golozar, A.
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Gong, M. C.
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Lai, L. Y. H.
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Lane, J. C. E.
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Lynch, K. E.
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Matheny, M. E.
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Mehta, P. P.
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Morales, D. R.
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Natarjan, K.
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Nyberg, Fredrik, ...
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Posada, J. D.
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Reich, C. G.
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Rijnbeek, P. R.
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Schilling, L. M.
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Shah, K.
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Shah, N. H.
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Subbian, V.
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Zhang, L.
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Zhu, H.
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Ryan, P.
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Prieto-Alhambra, ...
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Kostka, K.
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Duarte-Salles, T ...
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University of Gothenburg