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Is there an impact ...
Is there an impact of measurable residual disease as assessed by multiparameter flow cytometry on survival of AML patients treated in clinical practice? A population-based study
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- Rosso, Aldana (author)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Geriatrik,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Radiology Diagnostics, Malmö,Lund University Research Groups,Geriatrics,Lund Univ, Dept Clin Sci, Div Geriatr Med, Lund, Sweden; Lund Univ, Dept Translat Med, Diagnost Radiol, Lund, Sweden
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- Juliusson, Gunnar (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital,Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Lund, Sweden; Lund Univ, Stem Cell Ctr, Dept Lab Med, Lund, Sweden
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- Lorenz, F. (author)
- Norrland University Hospital,Umeå Univ Hosp, Dept Oncol & Hematol, Umeå, Sweden
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- Lehmann, Sören (author)
- Karolinska Institutet,Uppsala universitet,Hematologi
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- Derolf, Å (author)
- Karolinska University Hospital,Karolinska Univ Hosp, Dept Hematol, Huddinge, Sweden
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- Deneberg, S. (author)
- Karolinska Institutet
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- Jädersten, M. (author)
- Karolinska Institutet
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- Antunovic, Petar (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US,Linköping Univ Hosp, Dept Hematol, Linköping, Sweden
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- Cammenga, Jörg (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US,Linköping Univ Hosp, Dept Hematol, Linköping, Sweden
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- Möllgård, L. (author)
- Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Dept Hematol, Gothenburg, Sweden
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- Wennström, L. (author)
- Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Dept Hematol, Gothenburg, Sweden
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- Ölander, E. (author)
- Sundsvall Hospital,Sundsvall Hosp, Dept Hematol, Sundsvall, Sweden
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- Ehinger, Mats (author)
- Lund University,Lunds universitet,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Lund Univ, Skåne Univ Hosp, Dept Clin Sci Pathol, Lund, Sweden
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- Fogelstrand, Linda, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine,Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Dept Clin Chem, Gothenburg, Sweden; Univ Gothenburg, Inst Biomed, Dept Lab Med, Sahlgrenska Acad, Gothenburg, Sweden
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- Höglund, Martin (author)
- Uppsala universitet,Hematologi
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- Lazarevic, Vladimir Lj (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital,Skåne Univ Hosp, Dept Hematol Oncol & Radiat Phys, Lund, Sweden; Lund Univ, Stem Cell Ctr, Dept Lab Med, Lund, Sweden
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(creator_code:org_t)
- 2021-03-10
- 2021
- English.
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In: Leukemia and Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 62:8
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Abstract
Subject headings
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- The Swedish national guidelines for treatment of acute myeloid leukemia (AML) recommend analysis of measurable residual disease (MRD) by multiparameter flow cytometry (MFC) in bone marrow in the routine clinical setting. The Swedish AML registry contains such MRD data in AML patients diagnosed 2011–2019. Of 327 patients with AML (non-APL) with MRD-results reported in complete remission after two courses of intensive chemotherapy 229 were MRD-negative (70%), as defined by <0.1% cells with leukemia-associated immunophenotype in the bone marrow. MRD-results were reported to clinicians in real time. Multivariate statistical analysis adjusted for known established risk factors did not indicate an association between MFC-MRD and overall survival (HR: 1.00 [95% CI 0.61, 1.63]) with a median follow-up of 2.7 years. Knowledge of the importance of MRD status by clinicians and individualized decisions could have ameliorated the effects of MRD as an independent prognostic factor of overall survival. © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- allogenic stem cell transplantation
- AML
- MRD
- multiparameter flow cytometry
- overall survival
- AML; MRD; allogenic stem cell transplantation; overall survival; multiparameter flow cytometry
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Rosso, Aldana
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Juliusson, Gunna ...
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Lorenz, F.
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Lehmann, Sören
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Derolf, Å
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Deneberg, S.
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show more...
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Jädersten, M.
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Antunovic, Petar
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Cammenga, Jörg
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Möllgård, L.
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Wennström, L.
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Ölander, E.
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Ehinger, Mats
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Fogelstrand, Lin ...
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Höglund, Martin
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Lazarevic, Vladi ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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Leukemia and Lym ...
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University of Gothenburg
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Lund University
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Linköping University
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Uppsala University
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Karolinska Institutet