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Effect of Continuou...
Effect of Continuous Positive Airway Pressure on Weight and Local Adiposity in Adults with Obstructive Sleep Apnea A Meta-Analysis
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- Chen, B. X. (author)
- Shantou University,Shantou University Mental Health Center
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- Drager, L. F. (author)
- University of São Paulo
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- Peker, Yüksel, 1961 (author)
- Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Pittsburgh,Sahlgrenska Academy
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- Vgontzas, A. N. (author)
- Penn State Milton S. Hershey Medical Center
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- Phillips, C. L. (author)
- Woolcock Institute of Medical Research
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- Hoyos, C. M. (author)
- Woolcock Institute of Medical Research
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- Salles, G. F. (author)
- Federal University of Rio de Janeiro
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- Guo, M. L. (author)
- Shantou University
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- Li, Y. (author)
- Shantou University
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(creator_code:org_t)
- 2021
- 2021
- English.
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In: Annals of the American Thoracic Society. - 1546-3222 .- 2329-6933. ; 18:10, s. 1717-1727
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Abstract
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- Rationale: Evidence suggests that continuous positive airway pressure (CPAP) treatment promotes weight gain in patients with obstructive sleep apnea (OSA). It is unclear whether weight gain is influenced by CPAP adherence or comorbid disorders. Objectives: To examine the CPAP effects on body mass index (BMI) and local adiposity and the potential moderators of CPAP effects on BMI in patients with OSA. Methods: We searched PubMed/Medline, Embase, and Cochrane through December 2019. Randomized controlled trials of CPAP versus control treatment with >4 weeks' treatment were included. Results: A total of 39 randomized controlled trials with 6,954 subjects were included. In intention-to-treat analysis, the BMI increased significantly after CPAP treatment compared with control treatment (weighted mean difference [WMD], 0.148 kg/m(2); 95% confidence interval, 0.04-0.26; P = 0.001). In studies demonstrating an increase in the BMI, waist and neck circumferences were also significantly increased. Subgroup analyses revealed that an increased BMI was attributable to CPAP use of <5 h/night (WMD, 0.231) but was not attributable to CPAP use of.5 h/night (WMD, 0.001; between-group P value = 0.049). Furthermore, the BMI increased significantly in patients without cardiovascular disease (CVD; WMD, 0.200), whereas it decreased significantly in those with CVD at baseline (WMD, 20.188; between-group P value, 0.001). Moreover, the BMI increased significantly in patients with dysglycemia (WMD, 0.499) but did not increase in those without dysglycemia at baseline (WMD, 0.100; between-group P value = 0.032). Meta-regression confirmed the subgroup findings. Conclusions: The BMI increased significantly in patients with OSA after CPAP treatment, especially in those with CPAP use of <5 h/night, without CVD and/or with dysglycemia at baseline. CPAP use of at least 5 h/night seems to be necessary in mitigating the risk for weight gain in patients with OSA.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- obstructive sleep apnea
- continuous positive airway pressure
- body mass
- index
- weight control
- local adiposity
- leptin levels
- serum leptin
- cpap
- metabolism
- impact
- associations
- tolerance
- therapy
- obesity
- drive
- Respiratory System
- Body mass index
- Continuous positive airway pressure
- Local adiposity
- Obstructive sleep apnea
- Weight control
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Chen, B. X.
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Drager, L. F.
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Peker, Yüksel, 1 ...
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Vgontzas, A. N.
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Phillips, C. L.
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Hoyos, C. M.
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show more...
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Salles, G. F.
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Guo, M. L.
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Li, Y.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Annals of the Am ...
- By the university
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University of Gothenburg
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Lund University