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Dual-Energy Compute...
Dual-Energy Computed Tomography Compared to Lung Perfusion Scintigraphy to Assess Pulmonary Perfusion in Patients Screened for Endoscopic Lung Volume Reduction
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-08-10
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S. Karger AG,2021
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LIBRIS-ID:oai:gup.ub.gu.se/308976
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https://gup.ub.gu.se/publication/308976URI
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https://doi.org/10.1159/000517598DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Background: Endoscopic lung volume reduction (ELVR) using one-way endobronchial valves is a technique to reduce hyperinflation in patients with severe emphysema by inducing collapse of a severely destroyed pulmonary lobe. Patient selection is mainly based on evaluation of emphysema severity on high-resolution computed tomography and evaluation of lung perfusion with perfusion scintigraphy. Dual-energy contrast-enhanced CT scans may be useful for perfusion assessment in emphysema but has not been compared against perfusion scintigraphy. Aims: The aim of the study was to compare perfusion distribution assessed with dual-energy contrast-enhanced computed tomography and perfusion scintigraphy. Material and Methods: Forty consecutive patients with severe emphysema, who were screened for ELVR, were included. Perfusion was assessed with 99mTc perfusion scintigraphy and using the iodine map calculated from the dual-energy contrast-enhanced CT scans. Perfusion distribution was calculated as usually for the upper, middle, and lower thirds of both lungs with the planar technique and the iodine overlay. Results: Perfusion distribution between the right and left lung showed good correlation (r = 0.8). The limits of agreement of the mean absolute difference in percentage perfusion per region of interest were 0.75-5.6%. The upper lobes showed more severe perfusion reduction than the lower lobes. Mean difference in measured pulmonary perfusion ranged from -2.8% to 2.3%. Lower limit of agreement ranged from -8.9% to 4.6% and upper limit was 3.3-10.0%. Conclusion: Quantification of perfusion distribution using planar 99mTc perfusion scintigraphy and iodine overlays calculated from dual-energy contrast-enhanced CTs correlates well with acceptable variability.
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Walraven, K. H. M.
(author)
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Posthuma, R.
(author)
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Mitea, C.
(author)
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Slebos, D. J.
(author)
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Vanfleteren, Lowie E G WGothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xvanlo
(author)
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Göteborgs universitetInstitutionen för medicin
(creator_code:org_t)
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In:Respiration: S. Karger AG0025-79311423-0356
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