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Plasma proteins, co...
Plasma proteins, cognitive decline, and 20-year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies
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Lindbohm, J. V. (author)
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Mars, N. (author)
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Walker, K. A. (author)
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Singh-Manoux, A. (author)
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Livingston, G. (author)
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Brunner, E. J. (author)
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Sipila, P. N. (author)
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Saksela, K. (author)
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Ferrie, J. E. (author)
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Lovering, R. C. (author)
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Williams, S. A. (author)
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Hingorani, A. D. (author)
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Gottesman, R. F. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Kivimaki, M. (author)
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(creator_code:org_t)
- 2021-08-02
- 2022
- English.
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In: Alzheimers & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 18:4, s. 612-24
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Abstract
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- Introduction Plasma proteins affect biological processes and are common drug targets but their role in the development of Alzheimer's disease and related dementias remains unclear. We examined associations between 4953 plasma proteins and cognitive decline and risk of dementia in two cohort studies with 20-year follow-ups. Methods In the Whitehall II prospective cohort study proteins were measured using SOMAscan technology. Cognitive performance was tested five times over 20 years. Linkage to electronic health records identified incident dementia. The results were replicated in the Atherosclerosis Risk in Communities (ARIC) study. Results Fifteen non-amyloid/non-tau-related proteins were associated with cognitive decline and dementia, were consistently identified in both cohorts, and were not explained by known dementia risk factors. Levels of six of the proteins are modifiable by currently approved medications for other conditions. Discussion This study identified several plasma proteins in dementia-free people that are associated with long-term risk of cognitive decline and dementia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- cognitive decline
- cohort study
- dementia
- longitudinal study
- proteomics
- kinase substrate marcks
- natriuretic peptide
- alzheimers-disease
- apolipoprotein-e
- growth-factor
- amyloid-beta
- brain
- osteoprotegerin
- activation
- marker
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lindbohm, J. V.
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Mars, N.
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Walker, K. A.
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Singh-Manoux, A.
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Livingston, G.
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Brunner, E. J.
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show more...
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Sipila, P. N.
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Saksela, K.
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Ferrie, J. E.
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Lovering, R. C.
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Williams, S. A.
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Hingorani, A. D.
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Gottesman, R. F.
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Zetterberg, Henr ...
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Kivimaki, M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimers & Dem ...
- By the university
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University of Gothenburg