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"Global" cardiac at...
"Global" cardiac atherosclerotic burden assessed by artificial intelligence-based versus manual segmentation in F-18-sodium fluoride PET/CT scans: Head-to-head comparison
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- Piri, R. (author)
- Syddansk Universitet,University of Southern Denmark
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- Edenbrandt, Lars, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,University of Gothenburg
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Larsson, Måns, 1989 (author)
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- Enqvist, Olof, 1981 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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Skovrup, S. (author)
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Iversen, K. K. (author)
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- Saboury, B. (author)
- University of Maryland
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Alavi, A. (author)
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- Gerke, O. (author)
- Syddansk Universitet,University of Southern Denmark
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- Hoilund-Carlsen, P. F. (author)
- Syddansk Universitet,University of Southern Denmark
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(creator_code:org_t)
- 2021-08-12
- 2022
- English.
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In: Journal of Nuclear Cardiology. - : Springer Science and Business Media LLC. - 1071-3581 .- 1532-6551. ; 29:5, s. 2531-2539
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Abstract
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- Background Artificial intelligence (AI) is known to provide effective means to accelerate and facilitate clinical and research processes. So in this study it was aimed to compare a AI-based method for cardiac segmentation in positron emission tomography/computed tomography (PET/CT) scans with manual segmentation to assess global cardiac atherosclerosis burden. Methods A trained convolutional neural network (CNN) was used for cardiac segmentation in F-18-sodium fluoride PET/CT scans of 29 healthy volunteers and 20 angina pectoris patients and compared with manual segmentation. Parameters for segmented volume (Vol) and mean, maximal, and total standardized uptake values (SUVmean, SUVmax, SUVtotal) were analyzed by Bland-Altman Limits of Agreement. Repeatability with AI-based assessment of the same scans is 100%. Repeatability (same conditions, same operator) and reproducibility (same conditions, two different operators) of manual segmentation was examined by re-segmentation in 25 randomly selected scans. Results Mean (+/- SD) values with manual vs. CNN-based segmentation were Vol 617.65 +/- 154.99 mL vs 625.26 +/- 153.55 mL (P = .21), SUVmean 0.69 +/- 0.15 vs 0.69 +/- 0.15 (P = .26), SUVmax 2.68 +/- 0.86 vs 2.77 +/- 1.05 (P = .34), and SUVtotal 425.51 +/- 138.93 vs 427.91 +/- 132.68 (P = .62). Limits of agreement were - 89.42 to 74.2, - 0.02 to 0.02, - 1.52 to 1.32, and - 68.02 to 63.21, respectively. Manual segmentation lasted typically 30 minutes vs about one minute with the CNN-based approach. The maximal deviation at manual re-segmentation was for the four parameters 0% to 0.5% with the same and 0% to 1% with different operators. Conclusion The CNN-based method was faster and provided values for Vol, SUVmean, SUVmax, and SUVtotal comparable to the manually obtained ones. This AI-based segmentation approach appears to offer a more reproducible and much faster substitute for slow and cumbersome manual segmentation of the heart.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk laboratorie- och mätteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Laboratory and Measurements Technologies (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Image Processing (hsv//eng)
Keyword
- PET
- CT
- artificial intelligence
- heart
- sodium fluoride
- atherosclerosis
- microcalcification
- calcification
- calcium
- quantification
- association
- lesions
- Cardiovascular System & Cardiology
- Radiology
- Medical Imaging
- heart
Publication and Content Type
- ref (subject category)
- art (subject category)
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Piri, R.
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Edenbrandt, Lars ...
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Larsson, Måns, 1 ...
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Enqvist, Olof, 1 ...
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Skovrup, S.
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Iversen, K. K.
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Saboury, B.
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Alavi, A.
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Gerke, O.
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Hoilund-Carlsen, ...
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- MEDICAL AND HEALTH SCIENCES
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University of Gothenburg
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Chalmers University of Technology