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Reduced expression ...
Reduced expression of OXPHOS and DNA damage genes is linked to protection from microvascular complications in long-term type 1 diabetes: the PROLONG study
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- Ozgumus, T. (author)
- Department of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway
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- Sulaieva, Oksana (author)
- Medical Laboratory CSD, Vasylkivska Str. 45, Kyiv, Ukraine
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- Jessen, L. E. (author)
- Section for Bioinformatics, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark
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- Jain, Ruchi (author)
- Lund University,Lunds universitet,Öcellsfysiologi,Forskargrupper vid Lunds universitet,Islet cell physiology,Lund University Research Groups
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- Falhammar, H. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Nystrom, T. (author)
- Karolinska Institutet
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- Catrina, S. B. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Jorneskog, G. (author)
- Division of Internal Medicine, Department of Clinical Sciences, Karolinska Institute, Danderyd University Hospital, Stockholm, Sweden
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- Groop, Leif (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki
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- Eliasson, Mats (author)
- Umeå University,Umeå universitet,Avdelningen för medicin
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- Eliasson, Björn, 1959 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Department of Medicine, University of Gothenburg, Gothenburg, Sweden
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- Brismar, K. (author)
- Karolinska Institutet,Karolinska Institute
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- Stokowy, T. (author)
- Department of Clinical Science, University of Bergen, Bergen, Norway
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- Nilsson, Peter M. (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Lyssenko, Valeriya (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Bergen
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Department of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway Medical Laboratory CSD, Vasylkivska Str 45, Kyiv, Ukraine (creator_code:org_t)
- 2021-10-20
- 2021
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1
- Related links:
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Abstract
Subject headings
Close
- Type 1 diabetes is a chronic autoimmune disease requiring insulin treatment for survival. Prolonged duration of type 1 diabetes is associated with increased risk of microvascular complications. Although chronic hyperglycemia and diabetes duration have been considered as the major risk factors for vascular complications, this is not universally seen among all patients. Persons with long-term type 1 diabetes who have remained largely free from vascular complications constitute an ideal group for investigation of natural defense mechanisms against prolonged exposure of diabetes. Transcriptomic signatures obtained from RNA sequencing of the peripheral blood cells were analyzed in non-progressors with more than 30 years of diabetes duration and compared to the patients who progressed to microvascular complications within a shorter duration of diabetes. Analyses revealed that non-progressors demonstrated a reduction in expression of the oxidative phosphorylation (OXPHOS) genes, which were positively correlated with the expression of DNA repair enzymes, namely genes involved in base excision repair (BER) machinery. Reduced expression of OXPHOS and BER genes was linked to decrease in expression of inflammation-related genes, higher glucose disposal rate and reduced measures of hepatic fatty liver. Results from the present study indicate that at transcriptomic level reduction in OXPHOS, DNA repair and inflammation-related genes is linked to better insulin sensitivity and protection against microvascular complications in persons with long-term type 1 diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- vascular complications
- molecular-mechanisms
- mitochondrial
- hypoxia
- repair
- ros
- epidemiology
- pathogenesis
- stability
- disease
- Science & Technology - Other Topics
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Ozgumus, T.
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Sulaieva, Oksana
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Jessen, L. E.
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Jain, Ruchi
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Falhammar, H.
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Nystrom, T.
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show more...
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Catrina, S. B.
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Jorneskog, G.
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Groop, Leif
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Eliasson, Mats
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Eliasson, Björn, ...
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Brismar, K.
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Stokowy, T.
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Nilsson, Peter M ...
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Lyssenko, Valeri ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Scientific Repor ...
- By the university
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University of Gothenburg
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Umeå University
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Lund University
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Karolinska Institutet